305350-87-2
SL-327
CAS: 305350-87-2
Molecular Formula: C16H12F3N3S
305350-87-2 - Names and Identifiers
305350-87-2 - Physico-chemical Properties
| Molecular Formula | C16H12F3N3S |
| Molar Mass | 335.35 |
| Density | 1.40 |
| Melting Point | 127-128.2°C |
| Boling Point | 512.6±50.0 °C(Predicted) |
| Solubility | DMSO: 32mg/mL |
| Appearance | solid |
| Color | white |
| pKa | 3.42±0.10(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD06411432 |
| Use | SL327 |
| In vitro study | SL327 is a structural homolog of the specific MKK1/2 inhibitor U0126, which is water-soluble. When inhibiting MEK1 and MEK2, The IC50 is 0.18 μm and 0.22 μm, respectively. SL327 has no inhibitory effect on many other kinases, including PKA, PKC, or CamKII. |
| In vivo study | SL327 (50 mg/kg) can penetrate the blood-brain barrier and inhibit conditioned fear by inhibiting MAPK/ERK phosphorylation. SL327(30 mg/kg) significantly impaired spatial learning and memory in mice. SL327(50 mg/kg) inhibits Cocaine-induced properties. |
305350-87-2 - Risk and Safety
| WGK Germany | 3 |
305350-87-2 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.982 ml | 14.91 ml | 29.82 ml |
| 5 mM | 0.596 ml | 2.982 ml | 5.964 ml |
| 10 mM | 0.298 ml | 1.491 ml | 2.982 ml |
| 5 mM | 0.06 ml | 0.298 ml | 0.596 ml |
Last Update：2024-01-02 23:10:35
305350-87-2 - Reference Information
| biological activity | SL-327 is a selective MEK1/2 inhibitor with an IC50 of 0.18 μm/0.22 μm, there was no inhibitory activity against Erk1, MKK3, MKK4, c-JUN, PKC, PKA, and CamKII, able to pass the blood-brain barrier. SL-327 is a selective MEK1/2 inhibitor with an IC50 of 0.18 μm/0.22 μm, against Erk1, MKK3, MKK4, c-JUN, PKC, PKA, and CamKII has no inhibitory activity and can pass the blood-brain barrier. |
| Target | Value |
| MEK1 () | 0.18 μM |
| MEK2 | 0.22 μM |
| AP-1 | 2.03 μM |
Last Update：2024-04-09 15:16:56
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Product Name: SL-327 Visit Supplier Webpage Request for quotationCAS: 305350-87-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: SL327 Visit Supplier Webpage Request for quotationCAS: 305350-87-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: SL327 Visit Supplier Webpage Request for quotationCAS: 305350-87-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: SL-327 Visit Supplier Webpage Request for quotationCAS: 305350-87-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
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View History
305350-87-2
3,3,4,4,5,5,6,6,7,7,8,8,8-TRIDECAFLUOROOCTYL IODIDE
3-(3,4-DICHLOROPHENYL)-1,2,3-BENZOTRIAZIN-4(3H)-IMINE
Sulfuryl caprate
131673-98-8
78916-55-9
Arachidyl Stearate
433952-31-9
1-(azepane-1-sulfonyl)piperidine-4-carboxylic acid
Propanoic acid, 2-methyl-, (9S,10R)-9-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-10-yl ester
3,3,4,4,5,5,6,6,7,7,8,8,8-TRIDECAFLUOROOCTYL IODIDE
3-(3,4-DICHLOROPHENYL)-1,2,3-BENZOTRIAZIN-4(3H)-IMINE
Sulfuryl caprate
131673-98-8
78916-55-9
Arachidyl Stearate
433952-31-9
1-(azepane-1-sulfonyl)piperidine-4-carboxylic acid
Propanoic acid, 2-methyl-, (9S,10R)-9-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-10-yl ester