Molecular Formula | C9H8N2O |
Molar Mass | 160.17 |
Density | 1.204±0.06 g/cm3(Predicted) |
Melting Point | 110-114°C(lit.) |
Boling Point | 379.3±30.0 °C(Predicted) |
Flash Point | 183.2°C |
Solubility | soluble in Methanol |
Vapor Presure | 5.91E-06mmHg at 25°C |
Appearance | Crystalline Powder |
Color | Orange |
pKa | -1.69±0.10(Predicted) |
Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
Refractive Index | 1.599 |
MDL | MFCD00464114 |
Risk Codes | 22 - Harmful if swallowed |
Safety Description | 24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
HS Code | 29349990 |
Hazard Class | IRRITANT |
Uses | 3-phenyl-5-aminoisoxazole is a heterocyclic organic compound and can be used as a pharmaceutical intermediate. |
Preparation | The most common synthesis strategies of 3, 5-disubstituted isoxazoles include oxidative dehydrogenation of 2-isoxazoline, cyclization of alkynyl oxime ether, condensation of hydroxylamine and α,β-unsaturated carbonyl compounds or 1, 3-dicarbonyl compounds, α, cyclization of β-unsaturated oxime or β-ketooxime, etc. In this paper, 3,5-disubstituted isoxazole derivatives were constructed by 1,3-dipolar cycloaddition of substituted oxime and terminal alkynes under the action of base. The synthesis reaction formula is as follows: |