3-溴-5-氟-2-异丙氧基苯基硼酸

3-溴-5-氟-2-异丙氧基苯基硼酸 - Names and Identifiers

Name	[3-bromo-5-fluoro-2-(1-methylethoxy)phenyl]boronic acid
Synonyms	3-BROMO-2-FLUORO-2-ISOPROPOXYPHENYL- [3-bromo-5-fluoro-2-(1-methylethoxy)phenyl]boronic acid Boronic acid, [3-bromo-5-fluoro-2-(1-methylethoxy)phenyl]- (9CI)
CAS	352534-84-0
InChI	InChI=1/C9H11BBrFO3/c1-5(2)15-9-7(10(13)14)3-6(12)4-8(9)11/h3-5,13-14H,1-2H3

3-溴-5-氟-2-异丙氧基苯基硼酸 - Physico-chemical Properties

Molecular Formula	C9H11BBrFO3
Molar Mass	276.9
Density	1.53g/cm³
Melting Point	63-68°C(lit.)
Boling Point	390.5°C at 760 mmHg
Flash Point	190°C
Vapor Presure	8.46E-07mmHg at 25°C
Storage Condition	Inert atmosphere,Room Temperature
Refractive Index	1.54

3-溴-5-氟-2-异丙氧基苯基硼酸 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3

3-溴-5-氟-2-异丙氧基苯基硼酸 - Introduction

[3-bromo-5-fluoro-2-(1-methyllethoxy) phenyl]boronic acid is an organic compound whose chemical structural formula is C10H11BFNO3. It has the following properties:

1. Appearance: A white or almost white crystal powder.

2. Solubility: Soluble in organic solvents such as dimethyl sulfoxide (DMSO), dichloromethane (DCM) and ether, slightly soluble in water.

3. use:[3-bromo-5-fluoro-2-(1-methyllethoxy) phenyl]boronic acid is an important organic synthesis intermediate, commonly used in organic synthesis reaction. It can be used as a ligand to participate in metal-catalyzed reactions, such as platinum, palladium-catalyzed cross-coupling reactions, Suzuki coupling reactions, etc. In addition, it can also be used in areas such as drug development and materials science.

4. preparation method:[3-bromo-5-fluoro-2-(1-methyllethoxy) phenyl]boronic acid is usually synthesized by organic synthetic chemistry. A common preparation method is to react hydroquinone with bromoacetic acid to form the corresponding ester under alkaline conditions, and then convert the ester into the target compound by fluorination and boronic acid deacylation.

5. safety information: there is a lack of detailed research and reports on the specific safety information of [3-bromo-5-fluoro-2-(1-methyllethoxy) phenyl]boronic acid. However, as an organic compound, it may have certain toxicity and irritation to human body. During use, the corresponding laboratory safety practices should be followed, and appropriate personal protective measures should be taken, such as wearing gloves, glasses and protective clothing. Avoid contact with skin and eyes during handling and use. If contact occurs, rinse immediately with plenty of water. In case of accidental inhalation or ingestion, seek medical attention immediately.

Last Update：2024-04-09 02:00:45