Name | Benzalphthalide |
Synonyms | escalol547 Benzalphthalid Benzalphthalein Benzalphthalide benzylidenephthalide 3-benzylidene-phthalid 3-Benzylidenephthalide Phthalide, 3-benzylidene- (3Z)-3-Benzylidene-2-benzofuran-1(3H)-one (3E)-3-benzylidene-2-benzofuran-1(3H)-one 3-(phenylmethylene)-1(3h)-isobenzofuranon 1(3H)-Isobenzofuranone, 3-(phenylmethylene)- |
CAS | 575-61-1 |
EINECS | 209-388-8 |
InChI | InChI=1/C15H10O2/c16-15-13-9-5-4-8-12(13)14(17-15)10-11-6-2-1-3-7-11/h1-10H/b14-10+ |
Molecular Formula | C15H10O2 |
Molar Mass | 222.24 |
Density | 1.1404 (rough estimate) |
Melting Point | 99-102 °C (lit.) |
Boling Point | 323.41°C (rough estimate) |
Flash Point | 156.9°C |
Vapor Presure | 8.54E-06mmHg at 25°C |
Storage Condition | 2-8℃ |
Refractive Index | 1.6600 (estimate) |
MDL | MFCD00005929 |
Physical and Chemical Properties | Prismatic crystals. Melting point 108 °c (99-102 °c). |
Hazard Symbols | Xn - Harmful |
Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
WGK Germany | 3 |
RTECS | TI3686000 |
HS Code | 29329900 |
Use | pharmaceutical intermediates. |
production method | is obtained by condensation of phthalic anhydride with phenylacetic acid. Phthalic anhydride, phenylacetic acid and anhydrous sodium acetate are heated together for reaction, and the temperature is gradually increased to 240 ℃, and the reaction is carried out for 2-3H at this temperature. The reactant is cooled to 140 ℃, put into 95% ethanol, and refluxed for 1H, the crystals were cooled, filtered and dried to give benzylidene phthalides. |