3-Pentenoic acid, 2-amino-4-methyl-5-phosphono-, (3E)-
(E)-(+/-)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID
CAS: 127910-31-0
Molecular Formula: C6H12NO5P
3-Pentenoic acid, 2-amino-4-methyl-5-phosphono-, (3E)- - Names and Identifiers
3-Pentenoic acid, 2-amino-4-methyl-5-phosphono-, (3E)- - Physico-chemical Properties
| Molecular Formula | C6H12NO5P |
| Molar Mass | 209.14 |
| Density | 1.506±0.06 g/cm3(Predicted) |
| Boling Point | 523.1±60.0 °C(Predicted) |
| Solubility | H2O: ≥2mg/mL (warmed) |
| Appearance | powder |
| Color | white to beige |
| pKa | 1.83±0.10(Predicted) |
| Storage Condition | Desiccate at +4°C |
| In vitro study | In the hippocampal slice in vitro, CGP 37849 selectively and reversibly antagonizes NMDA-evoked increases in CA1 pyramidal cell firing rate. In slices bathed in medium containing low Mg 2+ levels, concentrations of CGP 37849 up to 10 μM suppresses burst firing evoked in CA1 neurones by stimulation of Schaffer collateral-commissural fibres without affecting the magnitude of the initial population spike. |
| In vivo study | CGP 37849 potently ( K i of 220 nM) and competitively inhibits NMDA-sensitive l-[ 3 H]-glutamate binding to postsynaptic density (PSD) fractins from rat brain. CGP 37849 inhibits the binding of the selective NMDA receptor antagonist, [ 3 H]-(±)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonate (CPP), with a K i of 35 nM. In vivo, oral administration to rats of CGP 37849 selectively blocks firing in hippocampal neurones induced by ionophoretically-applied NMDA, without affecting the responses to quisqualate or kainate. Oral administration to mice of CGP 37849 suppresses maximal electroshock-induced seizures in mice with an ED 50 of 21 mg/kg. |
3-Pentenoic acid, 2-amino-4-methyl-5-phosphono-, (3E)- - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
3-Pentenoic acid, 2-amino-4-methyl-5-phosphono-, (3E)- - References
| biological activity | CGP 37849 is a potent competitive orally active N-methyl-D-aspartate (NMDA) receptor antagonists. CGP 37849 is an anticonvulsant in rodents with antidepressant and anti-Anxiety effects. |
Last Update：2024-04-09 21:11:58
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View History
3-Pentenoic acid, 2-amino-4-methyl-5-phosphono-, (3E)-
2-(4-chlorophenyl)-6-(thiophen-2-yl)-4-(trifluoromethyl)pyridine-3-carbonitrile
Phosphoric acid dihydrogen 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-yl ester
1343061-06-2
1658467-44-7
70318-99-9
Alendronic Acid
1-Acridinol, 9-[[(4-chlorophenyl)methyl]amino]-1,2,3,4-tetrahydro-
MOLPORT-003-578-511
2,4(1H,3H)-Quinazolinedione, 1-[2-(dimethylamino)ethyl]-6,7-dimethoxy-3-(phenylmethyl)-
2-(4-chlorophenyl)-6-(thiophen-2-yl)-4-(trifluoromethyl)pyridine-3-carbonitrile
Phosphoric acid dihydrogen 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-yl ester
1343061-06-2
1658467-44-7
70318-99-9
Alendronic Acid
1-Acridinol, 9-[[(4-chlorophenyl)methyl]amino]-1,2,3,4-tetrahydro-
MOLPORT-003-578-511
2,4(1H,3H)-Quinazolinedione, 1-[2-(dimethylamino)ethyl]-6,7-dimethoxy-3-(phenylmethyl)-