127910-31-0
(E)-(+/-)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID
CAS: 127910-31-0
Molecular Formula: C6H12NO5P
127910-31-0 - Names and Identifiers
127910-31-0 - Physico-chemical Properties
| Molecular Formula | C6H12NO5P |
| Molar Mass | 209.14 |
| Density | 1.506±0.06 g/cm3(Predicted) |
| Boling Point | 523.1±60.0 °C(Predicted) |
| Solubility | H2O: ≥2mg/mL (warmed) |
| Appearance | powder |
| Color | white to beige |
| pKa | 1.83±0.10(Predicted) |
| Storage Condition | Desiccate at +4°C |
| In vitro study | In the hippocampal slice in vitro, CGP 37849 selectively and reversibly antagonizes NMDA-evoked increases in CA1 pyramidal cell firing rate. In slices bathed in medium containing low Mg 2+ levels, concentrations of CGP 37849 up to 10 μM suppresses burst firing evoked in CA1 neurones by stimulation of Schaffer collateral-commissural fibres without affecting the magnitude of the initial population spike. |
| In vivo study | CGP 37849 potently ( K i of 220 nM) and competitively inhibits NMDA-sensitive l-[ 3 H]-glutamate binding to postsynaptic density (PSD) fractins from rat brain. CGP 37849 inhibits the binding of the selective NMDA receptor antagonist, [ 3 H]-(±)-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonate (CPP), with a K i of 35 nM. In vivo, oral administration to rats of CGP 37849 selectively blocks firing in hippocampal neurones induced by ionophoretically-applied NMDA, without affecting the responses to quisqualate or kainate. Oral administration to mice of CGP 37849 suppresses maximal electroshock-induced seizures in mice with an ED 50 of 21 mg/kg. |
127910-31-0 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
127910-31-0 - References
| biological activity | CGP 37849 is a potent competitive orally active N-methyl-D-aspartate (NMDA) receptor antagonists. CGP 37849 is an anticonvulsant in rodents with antidepressant and anti-Anxiety effects. |
Last Update：2024-04-09 21:11:58
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View History
127910-31-0
N-(AMINOCARBONYL)-2-(2-NITROPHENOXY)ACETAMIDE
2-NAPHTHALENE-CARBOXAMIDE,3-HYDROXY-4-((2-METHOXY-5-((PHENYLAMINO)CARBONYL)PHENYL)AZO)-N-4-(CHLORO-2,5-DIMETHOXYLPHENYL)-
2-bromo-1-(3-bromophenyl)ethanone
1,3,3-trimethyl-6-[2-nitro-4-(trifluoromethyl)phenyl]-6-azabicyclo[3.2.1]octane
(R)-1-(5-Bromothiophen-2-yl)ethan-1-amine hydrochloride
N-(AMINOCARBONYL)-2-(2-NITROPHENOXY)ACETAMIDE
2-NAPHTHALENE-CARBOXAMIDE,3-HYDROXY-4-((2-METHOXY-5-((PHENYLAMINO)CARBONYL)PHENYL)AZO)-N-4-(CHLORO-2,5-DIMETHOXYLPHENYL)-
2-bromo-1-(3-bromophenyl)ethanone
1,3,3-trimethyl-6-[2-nitro-4-(trifluoromethyl)phenyl]-6-azabicyclo[3.2.1]octane
(R)-1-(5-Bromothiophen-2-yl)ethan-1-amine hydrochloride