3-Chloro-1,2-propanediol
3-Chloro-1,2-propanediol
CAS: 96-24-2
Molecular Formula: C3H7ClO2
3-Chloro-1,2-propanediol - Names and Identifiers
3-Chloro-1,2-propanediol - Physico-chemical Properties
| Molecular Formula | C3H7ClO2 |
| Molar Mass | 110.54 |
| Density | 1.322g/mLat 25°C(lit.) |
| Melting Point | -40°C |
| Boling Point | 213°C(lit.) |
| Flash Point | >230°F |
| Water Solubility | Soluble |
| Solubility | H2O: soluble |
| Vapor Presure | 0.04 mm Hg ( 25 °C) |
| Appearance | Liquid |
| Color | Clear pale yellow |
| Merck | 14,2145 |
| BRN | 635684 |
| pKa | 13.28±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | n20/D 1.480(lit.) |
| Physical and Chemical Properties | Density 1.322 melting point -40°C Boiling Point 213°C refractive index 1.479-1.481 flash point 135°C water Soluble |
| Use | Mainly used as a solvent for cellulose acetate, but also for the preparation of plasticizers, surfactants, dye intermediates and drugs |
3-Chloro-1,2-propanediol - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R60 - May impair fertility R21 - Harmful in contact with skin R23/25 - Toxic by inhalation and if swallowed. R41 - Risk of serious damage to eyes R39 - Danger of very serious irreversible effects R36 - Irritating to the eyes R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R40 - Limited evidence of a carcinogenic effect |
| Safety Description | S53 - Avoid exposure - obtain special instructions before use. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S39 - Wear eye / face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S38 - In case of insufficient ventilation, wear suitable respiratory equipment. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S28A - S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN 2689 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | TY4025000 |
| FLUKA BRAND F CODES | 3 |
| TSCA | Yes |
| HS Code | 29055998 |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | LD50 in mice, rats (g/kg): 0.16, 0.15 orally (Hine) |
3-Chloro-1,2-propanediol - Nature
Open Data Verified Data
a colorless liquid gradually becomes a yellow liquid with a microstrip green color after standing. There was a pleasant smell. The relative density (d40) was 1. 3204. Freezing point -40 °c. Refractive index 4809. Boiling point of 213 deg C (decomposition),116 deg C (1. 466kPa). Soluble in water, ethanol, ether and acetone. Slightly soluble in toluene, insoluble in benzene, petroleum ether and carbon tetrachloride. Easy to absorb moisture.
Last Update：2024-01-02 23:10:35
3-Chloro-1,2-propanediol - Preparation Method
Open Data Verified Data
- epichlorohydrin hydrolysis epichlorohydrin hydrolysis of 3 chlorine 1,2 A C = alcohol, and then fractionated to the finished product.
- chlorination of glycerol
Last Update：2022-01-01 10:15:43
3-Chloro-1,2-propanediol - Use
Open Data Verified Data
It is mainly used as a solvent for cellulose acetate and the like, and is used as a raw material for plasticizers, surfactants, dye intermediates, drugs such as chuanding and the like.
Last Update：2022-01-01 10:15:43
3-Chloro-1,2-propanediol - Safety
Open Data Verified Data
rat oral LD50 150mg/kg, mouse oral LD50 160mg/kg, rat inhalation mlcl 25mg/m3. See chloroethanol for its Protection Measure.
Last Update：2022-01-01 10:15:44
3-Chloro-1,2-propanediol - Reference Information
| freezing point | -40 ℃ |
| LogP | 0.5 at 25℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| (IARC) carcinogen classification | 2B (Vol. 101) 2013 |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| trait | colorless to light yellow liquid |
| Use | for organic synthesis. An intermediate of the drug chuanding; Used as a solvent for cellulose acetate and the like, and also used as an intermediate for plasticizers, surfactants and dyes. use as dye intermediate It is mainly used as a solvent for acetyl fiber and the like. Also used as plasticizers, surfactants, dye intermediates. In the pharmaceutical industry for the production of phlegm to cough medicine guaiacen oil ether, Antiasthmatic drugs theophylline, promethylol theophylline and so on. used in organic synthesis. An intermediate of the drug chuanding; Used as a solvent for cellulose acetate and the like, and also used as an intermediate for plasticizers, surfactants and dyes. It is mainly used as a solvent for cellulose acetate and the like, and is also used for preparing plasticizers, surfactants, dye intermediates, drugs and the like. It is used as a dye intermediate and is mainly used as a solvent for acetyl fiber and the like. Also used as plasticizers, surfactants, dye intermediates. In the pharmaceutical industry for the production of phlegm to cough medicine guaiacen oil ether, Antiasthmatic drugs theophylline, promethylol theophylline and so on. |
| production method | (1) is obtained by chlorination of glycerol. Glycerol and acetic acid were added to the reaction Pan, heated to 90-95 °c with stirring, and passed through dry hydrogen chloride gas until the reaction solution weight increased to 150% (theoretical value), which is the end point. The crude product was obtained by distillation under reduced pressure. After re-fractionation, the 128-132 °c (1.33-2.67kPa) fraction was collected to yield 3-chloro-1, 2-propanediol. (2) obtained by hydrolysis of epichlorohydrin. Epichlorohydrin was added into the reaction pot, stirred, diluted sulfuric acid was added to make the reaction solution acidic, and the temperature was raised and refluxed for 1H, and the obtained product was subjected to vacuum distillation to obtain a finished product. Raw material consumption quota: epichlorohydrin (>95%)1200kg/t, sulfuric acid 3kg/t. |
| category | toxic substances |
| toxicity grade | high toxicity |
| Acute toxicity | oral-rat LD50: 26 mg/kg; Oral-mouse LD50: 160 mg/kg |
| stimulation data | eye-rabbit 100 mg severe |
| explosive hazard characteristics | reaction with perchloric acid to generate sensitive explosive product |
| flammability hazard characteristics | when exposed to heat, the flame is flammable; Thermal decomposition of toxic chloride smoke |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored and transported separately from food raw materials and oxidants |
| fire extinguishing agent | foam, dry powder, carbon dioxide, water mist |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-26 11:43:20
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