Name | 3-bromo-2-chloroaniline |
Synonyms | 3-bromo-2-chloroaniline Benzenamine, 3-bromo-2-chloro- |
CAS | 56131-46-5 |
Molecular Formula | C6H5BrClN |
Molar Mass | 206.47 |
Density | 1.722±0.06 g/cm3(Predicted) |
Melting Point | 31-33 °C |
Boling Point | 267.1±20.0 °C(Predicted) |
pKa | 1.58±0.10(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
UN IDs | UN2019 |
Use | 3-bromo-2-chloroaniline is an organic intermediate, which can be obtained by reducing the nitro group from 1-bromo-2-chloro-3-nitrobenzene, or diazotization from 2-bromo-6-nitroaniline as raw material to prepare 1-bromo-2-chloro-3-nitrobenzene, the nitro group is then reduced to obtain 3-bromo-2-chloroaniline. |
Preparation | 1-bromo-2-chloro-3-nitrobenzene (1g,4.23mmol), iron powder (1.2g,21.5mmol) and ammonium chloride (228mg,4.3mmol) were added to ethanol and water (3mL/1.5mL). The mixture was stirred at 60°C for 2 hours. The reaction liquid is filtered out of the solid, the residual liquid is concentrated under reduced pressure and dissolved in ethyl acetate, washed with water and salt water respectively, and the organic phase is dried with anhydrous sodium sulfate and concentrated to obtain brown oily 3-bromo-2-chloroaniline 0.824g, The yield is 93%. LC-MS:205.9[M H ] |