3-(Methylsulfonyl)pyrrolidine

3-(Methylsulfonyl)pyrrolidine - Names and Identifiers

Name	3-(methylsulfonyl)pyrrolidine
Synonyms	INTRCHM-BB E8156 3-(Methylsulfonyl)pyrroli... 3-(METHYLSULFONYL)PYRROLIDINE 3-(methylsulfonyl)pyrrolidine 3-(METHANESULFONYL)PYRROLIDINE Pyrrolidine, 3-(methylsulfonyl)- pyrrolidine, 3-(methylsulfonyl)- 3-(Methylsulfonyl)pyrrolidine hydrochloride
CAS	433980-62-2
InChI	InChI=1/C5H11NO2S/c1-9(7,8)5-2-3-6-4-5/h5-6H,2-4H2,1H3

3-(Methylsulfonyl)pyrrolidine - Physico-chemical Properties

Molecular Formula	C5H11NO2S
Molar Mass	149.21
Density	1.23±0.1 g/cm3(Predicted)
Boling Point	326.9±31.0 °C(Predicted)
Flash Point	151.5°C
Vapor Presure	0.000209mmHg at 25°C
pKa	8.51±0.10(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
Refractive Index	1.499

3-(Methylsulfonyl)pyrrolidine - Risk and Safety

Hazard Symbols

Xi - Irritant

3-(Methylsulfonyl)pyrrolidine - Introduction

3-(methylsulfonyl)pyrrolidine(3-(methylsulfonyl)pyrrolidine) is an organic compound with the chemical formula C∞H∞NO₂. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: Colorless to light yellow solid
-Melting point: about 60-62 ℃
-Boiling point: about 280 ℃
-storage conditions: should be stored in a dry, ventilated place, avoid contact with oxidants

Use:
- 3-(methylsulfonyl)pyrrolidine is an important organic synthesis intermediate, which can be used to synthesize various organic compounds, such as drugs and pesticides.
-It can be used as an amine group protecting agent, and can react with amines to generate a stable methanesulfonyl protecting group, which is used for protection reactions in organic synthesis reactions.

Preparation Method:
- 3-(methylsulfonyl)pyrrolidine is usually prepared from 3-pyrrolidone by sulfonylation. First, 3-methanesulfonylpyrrolidone is produced by a reaction between a sulfuryl halide and a base, and then the ketone group is reduced to a pyrrolidine ring by a reduction reaction to give 3-(methylsulfonyl)pyrrolidine.

Safety Information:
- 3-(methylsulfonyl)pyrrolidine should be considered organic compounds and should be handled with appropriate laboratory safety measures, such as wearing protective gloves, goggles and laboratory coats.
-Avoid inhaling aerosols or dust. If inhaled, please remove to fresh air immediately and send to a doctor for treatment.
-Immediately after contact with skin or eyes, rinse with plenty of water for at least 15 minutes and seek medical assistance.
-During storage and handling, avoid contact with oxidants and strong acids to prevent dangerous reactions.

Last Update：2024-04-09 21:01:54