Name | furafylline |
Synonyms | FURAFYLLINE furafylline FURAFYLLINE INHIBITOR OF CYTOCHRO 3-(Furan-2-ylmethyl)-1,8-dimethyl-1H-purine-2,6(3H,7H)-dione 3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE 1H-Purine-2,6-dione, 3-(2-furanylmethyl)-3,9-dihydro-1,8-dimethyl- Furafylline,3-(2-Furanylmethyl)-3,7-dihydro-1,8-dimethyl-1H-purine-2,6-dione |
CAS | 80288-49-9 |
EINECS | 200-158-5 |
InChI | InChI=1/C12H12N4O3/c1-2-7-19-10-5-3-9(4-6-10)12-13-15-16(14-12)8-11(17)18/h2-6H,1,7-8H2,(H,17,18) |
InChIKey | KGQZGCIVHYLPBH-UHFFFAOYSA-N |
Molecular Formula | C12H12N4O3 |
Molar Mass | 260.25 |
Density | 1.443±0.06 g/cm3(Predicted) |
Melting Point | >162°C (dec.) |
Boling Point | 543.6±60.0 °C(Predicted) |
Flash Point | 259.1°C |
Solubility | ethanol: 0.33mg/mL |
Vapor Presure | 5.16E-11mmHg at 25°C |
Appearance | solid |
Color | white |
pKa | 8.62±0.70(Predicted) |
Storage Condition | 2-8°C(protect from light) |
Refractive Index | 1.627 |
In vivo study | Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC 50 of 0.07 μM in kinase experiment. Furafylline is a methylxanthine derivative that is introduced as a long-acting replacement for theophylline in the treatment of asthma. Administration of Furafylline is associated with an elevation in plasma levels of caffeine, due to inhibition of caffeine oxidation, a reaction catalysed by one or more hydrocarbon-inducible isoenzymes of P450. Furafylline has either very little or no effect on human monooxygenase activities catalysed by other isoenzymes of P450, including P4501ID1, P4501IC, P450IIIA. |
WGK Germany | 3 |
Reference Show more | 1. [IF=8.071] Xia Lv et al.Regioselective hydroxylation of carbendazim by mammalian cytochrome P450: A combined experimental and computational study.Environ Pollut. 2022 Jan;293:118523 |
biological activity | Furafylline is a potent and selective inhibitor of human cytochrome p450ia2, the IC50 value was 0.07 μm. |
Target | IC50: 0.07 μm (human cytochrome P450IA2) |