3-(2,7-二甲氧基AC啶-9-基硫基)丙-1-胺
3-(2,7-dimethoxyacridin-9-ylthio)propan-1-amine
CAS: 184582-62-5
Molecular Formula: C18H20N2O2S
3-(2,7-二甲氧基AC啶-9-基硫基)丙-1-胺 - Names and Identifiers
3-(2,7-二甲氧基AC啶-9-基硫基)丙-1-胺 - Physico-chemical Properties
| Molecular Formula | C18H20N2O2S |
| Molar Mass | 328.43 |
| Density | 1.25±0.1 g/cm3(Predicted) |
| Boling Point | 536.1±40.0 °C(Predicted) |
| Solubility | DMSO: soluble20mg/mL, clear |
| Appearance | powder |
| Color | white to light brown |
| pKa | 9.33±0.10(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | LDN-192960 (10 μM) is selective and inhibits ten of the other kinases by ≥90%, with only five being potently inhibited (IC 50 <1 μM), including CLK1 (IC 50 =0.21 μM), DYRK1A (IC 50 = 0.10 μM), DYRK2 (IC 50 =2 nM), DYRK3 (IC 50 =19 nM) and PIM1 (IC 50 =0.72 μM).LDN-0192960 (0-5 μM; 2 hours) demonstrates that the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells overexpressing Haspin with an EC 50 of 1.17 μM.LDN-0192960 (0-1 μM; 1 hour incubation in the presence of nocodazole and MG132) demonstrates the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells synchronized in mitosis with an EC 50 of 0.02 μM. |
3-(2,7-二甲氧基AC啶-9-基硫基)丙-1-胺 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
3-(2,7-二甲氧基AC啶-9-基硫基)丙-1-胺 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.045 ml | 15.224 ml | 30.448 ml |
| 5 mM | 0.609 ml | 3.045 ml | 6.09 ml |
| 10 mM | 0.304 ml | 1.522 ml | 3.045 ml |
| 5 mM | 0.061 ml | 0.304 ml | 0.609 ml |
Last Update：2024-01-02 23:10:35
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View History
3-(2,7-二甲氧基AC啶-9-基硫基)丙-1-胺
LABOTEST-BB LT00451972
Methanone, 2-azaspiro[5.5]undec-8-en-2-yl-1-pyrrolidinyl-
N1-(5-甲基异唑基-3-基)磺胺-13C6
3-乙酰氨基噻吩-2-甲酸
boc-d-3-氨基-3-(3-溴苯基)丙酸
5-溴-4,6-二羟基吡啶-3-羧酸甲酯
5-甲酰基-2,4-二甲基吡咯-3-羧酸
2-氨基-4-[3-(苄氧基)苯基]-1H-吡咯-3-甲腈
1-Fluoro-4-((2-(4-((1-methylethyl)thio)phenyl)-2-methylpropoxy)methyl) -2-phenoxybenzene
LABOTEST-BB LT00451972
Methanone, 2-azaspiro[5.5]undec-8-en-2-yl-1-pyrrolidinyl-
N1-(5-甲基异唑基-3-基)磺胺-13C6
3-乙酰氨基噻吩-2-甲酸
boc-d-3-氨基-3-(3-溴苯基)丙酸
5-溴-4,6-二羟基吡啶-3-羧酸甲酯
5-甲酰基-2,4-二甲基吡咯-3-羧酸
2-氨基-4-[3-(苄氧基)苯基]-1H-吡咯-3-甲腈
1-Fluoro-4-((2-(4-((1-methylethyl)thio)phenyl)-2-methylpropoxy)methyl) -2-phenoxybenzene