3-(1,2,3,6-TETRAHYDROPYRIDIN-4-YL)-1H-INDOLE

3-(1,2,3,6-TETRAHYDROPYRIDIN-4-YL)-1H-INDOLE - Names and Identifiers

Name	3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole
Synonyms	3-(1,2,3,6-Tetrahydro-4-pyridyl)indole 3-(1,2,3,6-TETRAHYDRO-4-PYRINYL)-1H-INDOLE 3-(1,2,3,6-TETRAHYDROPYRIDIN-4-YL)-1H-INDOLE 3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole 4-(1H-Indol-3-yl)-1,2,3,6-tetrahydropyridine 1H-Indole, 3-(1,2,3,6-tetrahydro-4-pyridinyl)- 3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-ol 3-(1,2,3,6-TETRAHYDROPYRIDIN-4-YL)-1H-INDOL-5-OL
CAS	65347-55-9
InChI	InChI=1/C13H14N2O/c16-10-1-2-13-11(7-10)12(8-15-13)9-3-5-14-6-4-9/h1-3,7-8,14-16H,4-6H2

3-(1,2,3,6-TETRAHYDROPYRIDIN-4-YL)-1H-INDOLE - Physico-chemical Properties

Molecular Formula	C13H14N2
Molar Mass	198.26
Density	1.269g/cm³
Melting Point	177-182°C
Boling Point	467°C at 760 mmHg
Flash Point	236.2°C
Vapor Presure	2.42E-09mmHg at 25°C
Appearance	Solid
Storage Condition	2-8°C
Refractive Index	1.691

3-(1,2,3,6-TETRAHYDROPYRIDIN-4-YL)-1H-INDOLE - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Class	IRRITANT

3-(1,2,3,6-TETRAHYDROPYRIDIN-4-YL)-1H-INDOLE - Introduction

3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole is an organic compound also known as 3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole. The following is a detailed description of its nature, use, formulation and safety information:

Nature:
-Chemical formula: C14H16N2
-Molecular weight: 212.29g/mol
-Appearance: White crystalline solid
-melting point: 101-104 ℃
-Thermal stability: unstable at high temperature and high pressure
-Solubility: Slightly soluble in water, soluble in ethanol, ether, dimethyl sulfoxide and other organic solvents

Use:
3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole is a commonly used organic synthesis intermediate, which can be used to synthesize a variety of biologically active compounds, such as drugs, dyes and pesticides. It has a wide range of applications in the field of medicine, for the development of anti-tumor, anti-cancer and anti-inflammatory drugs.

Preparation Method:
3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole can be prepared by the following steps:
1. Under alkaline conditions, pyridoxine is condensed with an appropriate aromatic aldehyde to obtain pyridoxine aldehyde.
2. The pyridoxine aldehyde is hydrogenated with an amino ketone (such as 1H-indol-3-one) in the presence of a hydrogenating agent to obtain the target product.

Safety Information:
There is no specific literature report on the safety information of 3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole. However, in general, any chemical should be handled and stored under appropriate laboratory conditions. During the operation, the safe handling procedures for chemicals should be followed, including wearing personal protective equipment, such as protective glasses and laboratory gloves.

Last Update：2024-04-09 21:54:55