Molecular Formula | C6H2BrCl2F |
Molar Mass | 243.89 |
Density | 1.823 |
Boling Point | 234℃ |
Flash Point | 96℃ |
Vapor Presure | 23.8-112Pa at 30-50℃ |
Appearance | Liquid |
Storage Condition | Sealed in dry,2-8°C |
Refractive Index | 1.567 |
LogP | 4.4 at 20℃ and pH7 |
Use | 3, 5-dichloro-4-fluorobromobenzene is an intermediate in organic synthesis, can be used in the laboratory of organic synthesis and pharmaceutical research and development process. |
preparation | (1) the ammonium salt and the aqueous solution of sodium nitrite are simultaneously fed into a tubular reactor for performing a tubular diazotization reaction to obtain a diazonium salt Intermediate; the ammonium salt is prepared by dissolving 3, 5-dichloro-4-fluoroaniline in sulfuric acid;(2) dissolving cuprous bromide in hydrobromic acid and warming up to 100-130 °c, the diazonium salt intermediate obtained in the step (1) was added dropwise for reaction, and after the reaction was completed, the 3, 5-dichloro-4-fluorobromobenzene was obtained by post-treatment. |