3,5-Bis(Benzoyl)-1-Methanesulfonyloxy-2-Deoxy-2,2-Difluororibose - Names and Identifiers
Name | 3,5-Bis(benzoyl)-1-methanesulfonyloxy-2-deoxy-2,2-difluororibose(β-form)
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Synonyms | Gemcitabine Impurity 4 β-D-erythro-Pentofuranose 3,5-Bis(benzoyl)-1-methanesulfonyloxy-2-deoxy-2,2-difluororibose 3,5-Bis(Benzoyl)-1-Methanesulfonyloxy-2-Deoxy-2,2-Difluororibose 3,5-Bis(benzoyl)-1-methanesulfonyloxy-2-deoxy-2,2-difluororibose(β-form) 3,5-Di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-ribofuranose 3,5-Di-O-benzoyl-2-deoxy-2,2-difluoro-1-O- methanesulfonyl-D-ribofuranose ((2R,3R,5R)-3-(Benzoyloxy)-4,4-difluoro-5-((methyl-sulfonyl)oxy)tetrahydrofuran-2-yl)methyl be (3S,4R)-3-Benzoyl-2,2-difluoro-3,4,5-trihydroxy-6-oxo-6-phenylhexanoic Methanesulfonic anhydride ((2R,3R,5R)-3-(Benzoyloxy)-4,4-difluoro-5-((methyl-sulfonyl)oxy)tetrahydrofuran-2-yl)methyl benzo
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CAS | 134877-43-3
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EINECS | 1312995-182-4 |
InChI | InChI=1/C20H18F2O9S/c1-32(27,28)31-19(26)20(21,22)16(30-18(25)14-10-6-3-7-11-14)15(23)12-29-17(24)13-8-4-2-5-9-13/h2-11,15-16,23H,12H2,1H3/t15-,16-/m1/s1 |
3,5-Bis(Benzoyl)-1-Methanesulfonyloxy-2-Deoxy-2,2-Difluororibose - Physico-chemical Properties
Molecular Formula | C20H18F2O8S
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Molar Mass | 456.41 |
Density | 1.46±0.1 g/cm3(Predicted) |
Boling Point | 588.4±50.0 °C(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.555 |
3,5-Bis(Benzoyl)-1-Methanesulfonyloxy-2-Deoxy-2,2-Difluororibose - Introduction
2-Deoxy-2, 2-difluoro-D-ribofuranosyl-3, 5-dixyloyl-1-methanesulfonate (beta form), also known as DAA-F-β-TIPS, is a chemical reagent. The following is a description of the properties, uses, preparation and safety information of this compound:
Nature:
-Appearance: Colorless or light yellow solid
-melting point: about 70-72 ℃
-Molecular formula: C22H21F2O5S
-Molecular weight: 442.47g/mol
Use:
DAA-F-β-TIPS is generally used as a protecting group in organic synthesis. It stabilizes and protects the hydroxyl (OH) functional groups from unintended reactions under the reaction conditions. The compounds are commonly used in the synthesis of oligonucleotides in nucleic acid sequences for the synthesis of highly efficient nanohybrids and ordered covalent organic frameworks, among others.
Preparation Method:
The preparation of DAA-F-β-TIPS is generally carried out by means of chemical synthesis. The usual synthetic method involves reacting 2-deoxy-D-ribofuranose with 3,5-xylyl chloride and then with mesylate to give the desired product.
Safety Information:
When using DAA-F-β-TIPS, it is necessary to strictly follow relevant safety procedures, such as wearing appropriate personal protective equipment (such as laboratory gloves and goggles). In addition, the compound is irritating and corrosive and may be harmful to the skin, eyes and mucous membranes. Therefore, in the operation and storage should avoid contact, avoid inhalation of its dust or vapor. After exposure, rinse immediately with plenty of water and consult a professional doctor for advice.
Please note that due to the nature of chemical reagents and the diversity of usage methods, please refer to specific chemical literature or consult relevant professionals for confirmation before use.
Last Update:2024-04-10 22:29:15