Molecular Formula | C15H12O4 |
Molar Mass | 256.25 |
Melting Point | 181-182 °C |
Boling Point | 528.3°C at 760 mmHg |
Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents |
Appearance | Powder |
Storage Condition | 2-8°C |
Application | in the diabetes model of mice induced by alloxan, and KK-Ay mice after taking 200mg/(kg • d), blood glucose and free fatty acid levels decreased significantly within 2 weeks; In addition, there are good antibacterial and anti-allergic effects. |
preparation | take the dried leaves of C. Bovis 500g to be crushed into coarse powder, add water to extract 2 times, combine the extracts, concentrate under reduced pressure to a density of 1.14(60 ℃), add ethanol to make the alcohol concentration reach 60%, refrigerated at 0~2 ℃ for 24h, filter, filtrate is concentrated under reduced pressure to obtain extract; Dissolve the extract with methanol, silica gel was added to stir sample, and after drying, column chromatography was performed. Gradient elution was carried out by petroleum ether-ethyl acetate system, and the eluent was combined under the reference of thin layer chromatography. The petroleum ether-ethyl acetate (89: 11~87: 13) repeated recrystallization from ethanol was carried out to obtain the compound of phthalide (white crystals, 1.0g). |