3,4,5,6-tetrahydrouridine
Tetrahydrouridine
CAS: 18771-50-1
Molecular Formula: C9H16N2O6
3,4,5,6-tetrahydrouridine - Names and Identifiers
3,4,5,6-tetrahydrouridine - Physico-chemical Properties
| Molecular Formula | C9H16N2O6 |
| Molar Mass | 248.23 |
| Density | 1.622±0.06 g/cm3(Predicted) |
| Melting Point | >195°C (dec.) |
| Boling Point | 668.6±55.0 °C(Predicted) |
| Appearance | Form Solid, color White to Off-White |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Stability | Light Sensitive |
| Physical and Chemical Properties | Bioactive Tetrahydrouridine dihydrate (THU dihydrate) is a potent inhibitor of cytidine deaminase (CDA), which competitively blocks the active site of the enzyme. |
3,4,5,6-tetrahydrouridine - Uses and synthesis methods
Target
cytidine deaminase (CDA)
in vitro studies
Tetrahydrouridine (THU) is a specific inhibitor of cytidine deaminase (CDA) which can suppress deamination in the catabolism of cytotoxic deoxycytidine analogues like ara-C and Gemcitabine. To test how Tetrahydrouridine affects the Gemcitabine-mediated anti-neoplastic effect on pancreatic and lung carcinoma cells, a combination therapy is performed. As expected, high CDA expression in BxPC-3 and H441 results in improved Gemcitabine sensitivity after a 100 µM Tetrahydrouridine treatment. The sensitivity of BxPC-3 and H441 cell lines increases by as much as approximately 2.1 and 4.4 fold respectively. On the other hand, MIAPaCa-2 and H1299 cells unexpectedly become more sensitive to Gemcitabine with low CDA expression. MIAPaCa-2 and H1299 cells show a change in IC 50 of 2.2 and 2.3 fold respectively. However, Panc-1 and H322 cells do not show significant changes in drug sensitivity. These data suggested that Tetrahydrouridine can sensitize some pancreatic and lung carcinoma cells to Gemcitabine-induced cell death regardless of CDA expression levels. Tetrahydrouridine inhibits S-phase without apoptosis.
In vivo studies
Administration of 167 mg/kg Tetrahydrouridine (THU) followed by 1.0 mg/kg DAC results in death in one male and eight females. Animals surviving to scheduled termination are generally asymptomatic with no treatment related effects observed in body weights, food consumption, clinical chemistry and urinalysis for a treatment up to 1.0 mg/kg DAC in combination with 167 mg/kg Tetrahydrouridine in animals.
Last Update：2024-04-09 21:22:08
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Product Name: THU; NSC-112907 Visit Supplier Webpage Request for quotationCAS: 18771-50-1
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Product Name: TETRAHYDROURIDINE Visit Supplier Webpage Request for quotationCAS: 18771-50-1
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Product Name: Tetrahydrouridine Visit Supplier Webpage Request for quotationCAS: 18771-50-1
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Email: Int06@meryer.com
Mobile: +86-18821248368
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Product Name: Tetrahydrouridine Visit Supplier Webpage Request for quotation
CAS: 18771-50-1
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Email: 3008007409@qq.com
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CAS: 18771-50-1
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View History
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