Molecular Formula | C12H15N3O2 |
Molar Mass | 233.27 |
Density | 1.258±0.06 g/cm3(Predicted) |
Solubility | 10 mM in DMSO |
pKa | 9.15±0.70(Predicted) |
Storage Condition | -20℃ |
In vitro study | Pardoprunox (SLV-308) acts as a potent but partial D2 receptor agonist (pEC 50 = 8.0 and pA 2 =8.4) with an efficacy of 50% on forskolin stimulated cAMP accumulation. At human recombinant dopamine D3 receptors, Pardoprunox acts as a partial agonist in the induction of [(35)S]GTPgammaS binding (intrinsic activity of 67%; pEC 50 =9.2) and antagonized the dopamine induction of [(35)S]GTPgammaS binding (pA 2 =9.0). Pardoprunox acts as a full 5-HT1A receptor agonist on forskolin induced cAMP accumulation at cloned human 5-HT1A receptors but with low potency (pEC 50 =6.3). |