26258-21-9

26258-21-9 - Names and Identifiers

Name	1,3,4,5,6,7-Hexahydro-2H-benzimidazol-2-one
Synonyms	185897 RARECHEM AQ NN 0100 2,3,4,5,6,7-Hexahydro-1H-benzimidazol-2-on 1,3,4,5,6,7-Hexahydro-2H-benzimidazol-2-one 2H-Benzimidazol-2-one, 1,3,4,5,6,7-hexahydro- 1,3,4,5,6,7-hexahydro-2H-benzo[d]imidazol-2-one 4,5,6,7-Tetrahydro-1H-benzo[d]imidazol-2(3H)-one
CAS	26258-21-9

26258-21-9 - Physico-chemical Properties

Molecular Formula	C7H10N2O
Molar Mass	138.17
Density	1.22±0.1 g/cm3(Predicted)
Melting Point	340-341 °C (decomp)
pKa	11.99±0.20(Predicted)
Sensitive	Irritant
MDL	MFCD03413592

26258-21-9 - Introduction

1,3,4,5,6, is an organic compound with the chemical formula C8H10N2O. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: Colorless or slightly yellow crystalline solid.
-Solubility: Can be dissolved in organic solvents, such as ethanol, dimethyl sulfoxide and dichloromethane, insoluble in water.
-Melting point: about 108-113 degrees Celsius.
-Stability: relatively stable at room temperature, but avoid prolonged exposure to strong light and high temperature conditions. Slightly unstable under acidic conditions and strong oxidants.

Use:
-Pharmaceutical field: 1,3,4,5,6, benzimidazole is an important intermediate of benzimidazole compounds, which is widely used in the preparation of synthetic drugs, colchicine compounds and other bioactive molecules.
-Research field: As a functional compound, it can be used in organic synthesis reactions and catalytic reactions.

Preparation Method:
1,3,4,5,6, can be synthesized by the following steps:
1. Aniline reacts with acetaldehyde to give 1,3-butanediol diethyl ether compound.
2. After the condensation reaction of methyl carbamate, 1,3,4,5, 6,7-hexahydro -2H-benzo [d] imidazole -2-methanol compound is generated.
3. Finally, it is converted into 1,3,4,5,6 by oxidation and alkaline treatment.

Safety Information:
- 1,3,4,5,6, Toxicity data is limited, but it is generally considered to be a relatively safe compound.
-During operation, it is recommended to wear personal protective equipment such as protective gloves, protective glasses and protective clothing.
-Avoid swallowing or inhaling compounds. In case of accidental contact, immediately flush the affected area with plenty of water and seek medical help.
-When storing, keep the compound in a dry, cool, well-ventilated place away from fire and oxidizing agents.

Last Update：2024-04-09 15:18:09