3-(3-fluoro-phenyl)-3-oxo-propionic acid methyl ester is an organic compound with the chemical formula C10H9FO3. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: colorless liquid
-Melting point:-10 ℃
-Boiling point: 225 ℃
-Density: 1.233g/cm³
-Refractive Index: 1.507
-Solubility: Soluble in organic solvents such as ethanol and dichloromethane
Use:
- 3-(3-fluoro-phenyl)-3-oxo-propionic acid methyl ester is an organic synthesis intermediate commonly used in the synthesis of other organic compounds, such as drugs and pesticides.
-It can be used as a raw material for the development of new drugs and has biological activities such as anti-inflammatory, anti-tumor or anti-virus.
Method:
- 3-(3-fluoro-phenyl)-3-oxo-propionic acid methyl ester can be obtained by reacting acetophenone with 3-fluorobenzoic acid and other reagents.
-In the reaction, acetophenone is first reacted with an electrophilic reagent (such as boron reagent) to generate alcohol. The alcohol is then converted to a ketone by an oxidation reaction. Finally, a fluorine atom is introduced by reaction with a fluorine reagent to obtain the target product.
Safety Information:
- 3-(3-fluoro-phenyl)-3-oxo-propionic acid methyl ester is a flammable liquid and should be kept away from open flames and high temperatures.
-During use, care should be taken to avoid contact with skin and eyes. If you accidentally touch, rinse immediately with plenty of water.
-Wear personal protective equipment such as protective gloves, goggles and protective clothing during operation.
-When storing, Please seal it in a cool, dry place.
Please note that the preparation and use of chemicals may have certain risks. Please take corresponding safety measures according to the specific situation.