252882-61-4 - Names and Identifiers
Name | Spiro[indoline-3,4'-piperidin]-2-one
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Synonyms | SPIRO[INDOLINE-3,4'-PIPERIDIN]-2-ONE Spiro[indoline-3,4'-piperidin]-2-one spiro[1H-indole-3,4'-piperidine]-2-one Spiro[3H-indole-3,4'-piperidin]-2(1H)-one 1,2-dihydrospiro[indole-3,4'-piperidine]-2-one 1,2-Dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine]
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CAS | 252882-61-4
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252882-61-4 - Physico-chemical Properties
Molecular Formula | C12H14N2O
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Molar Mass | 202.25 |
Density | 1.23±0.1 g/cm3(Predicted) |
Boling Point | 413.2±45.0 °C(Predicted) |
pKa | 13.94±0.20(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
Sensitive | Irritant |
MDL | MFCD12198581 |
252882-61-4 - Introduction
Spiro[indoline-3,4 '-piperidin]-2-one, commonly known as SPIRO ketone, is an organic compound. Its chemical structure contains a spiro ring structure, which is connected by indoline and piperidine rings.
Some of the key properties of SPIRO ketones include:
-Appearance: SPIRO ketone is a white crystalline solid.
-Solubility: SPIRO ketone is soluble in common organic solvents such as methanol, ethanol and dimethyl sulfoxide.
-Melting point: The melting point of SPIRO ketone is about 150-153°C.
SPIRO ketones have some important applications in pharmaceutical research and organic synthesis:
-Drug research: As a part of the drug molecular skeleton, SPIRO ketone has a variety of activities, such as anti-inflammatory, anti-tumor, analgesic, etc., so it has potential application prospects in drug research and development.
-Organic synthesis: The spiro structure of SPIRO ketone structure makes it have important applications in organic synthesis, which can be used as a stereo control element or provide molecular diversity.
About the method of preparing SPIRO ketone, there are mainly the following:
-reaction of indole and ketone: SPIRO ketone product is generated by the reaction of indole and ketone substrate under certain conditions.
-Catalyst-assisted reaction: Use a catalyst to react indole and ketone substrates to improve reaction efficiency and selectivity.
Safety Information for SPIRO Ketones There are no specific studies for this compound. However, in general, chemicals should follow basic safety procedures during handling and use, including wearing appropriate protective equipment, avoiding contact with skin and eyes, avoiding inhalation or ingestion, maintaining good ventilation, and complying with relevant regulations and laws.
Please note that the information provided here is for reference only and does not constitute specific advice on any particular compound. Please ensure that you understand and follow appropriate safety guidelines and regulations before using or handling any chemical substance.
Last Update:2024-04-09 21:54:55