Molecular Formula | C15H20O7 |
Molar Mass | 312.32 |
Density | 1.2307 (rough estimate) |
Melting Point | 222-223℃ |
Boling Point | 372.24°C (rough estimate) |
Flash Point | 2 °C |
Appearance | neat |
Color | Crystals from MeOH |
pKa | 11.78±0.70(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.4790 (estimate) |
Physical and Chemical Properties | The specific rotation is 24D 21.54 (c = 1.3 in ethanol) |
Risk Codes | R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed. R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
Safety Description | S22 - Do not breathe dust. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S28 - After contact with skin, wash immediately with plenty of soap-suds. S16 - Keep away from sources of ignition. |
UN IDs | UN 2811 6.1/PG 1 |
WGK Germany | 3 |
RTECS | YD0165000 |
HS Code | 38220090 |
Hazard Class | 6.1(a) |
Packing Group | I |
Toxicity | LD50 i.p. in mice: 40 mg/10 g (Tatsuno) |
Biological activity
Nivalenol is a type B trichloroethylene toxin (B trichotecenes toxins) produced by Fusarium graminearum (Fusarium graminearum), which is a fungal metabolite present in agricultural products. Nivalenol induce cell death through caspase-dependent mechanisms and intrinsic apoptotic (apoptotic) pathways. Nivalenol affects the immune system, causes vomiting, growth retardation, reproductive disorders and has hematotoxic/myelotoxic effects.
Target
Caspase