2310262-11-2

Name	PDK4-IN-1 hydrochloride
Synonyms	PDK4-IN-1 hydrochloride PDK4-IN-1 HYDROCHLORIDE 1-(1-(Piperidin-4-yl)-1H-pyrazol-4-yl)anthracene-9,10-dione hydrochloride
CAS	2310262-11-2

Molecular Formula	C22H20ClN3O2
Molar Mass	393.87
Storage Condition	Inert atmosphere,Room Temperature

biological activity	PDK4-IN-1 hydrochloride is an anthraquinone derivative and also a potent, an orally active Pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 value of 84 nM. PDK4-IN-1 hydrochloride effectively inhibits cell transformation and cell proliferation and induces apoptosis. PDK4-IN-1 hydrochloride has anti-diabetic, anti-cancer and anti-allergic effects.
Target	IC50: 84 nM (Pyruvate dehydrogenase kinase 4 (PDK4))
Cell Line:	HCT116 and RKO cells HCT116 and RKO cells HEK293T human embryonic kidney cells
Concentration:	50 μM 10 μM, 25 μM, 50 μM 10 μM
Incubation Time:	0 hour, 24 hours, 48 hours, 72hours 24 hours 24 hours
Result:	Significantly impeded the proliferation of human colon cancer cell lines, HCT116 and RKO. Dose-dependently increased apoptosis. Inhibited phosphorylation of Ser 232 , Ser 293 , and Ser 300 of PDHE1α. Significantly improved glucose tolerance.
Animal Model:	C57BL/6J mice (8-week old) fed with high-fat diet
Dosage:	100 mg/kg
Administration:	Oral administration; daily; for 1 week

Last Update：2024-04-09 21:54:55

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CAS: 2310262-11-2
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QQ: 2881950922

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CAS: 2310262-11-2
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QQ: 495145328

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