Name | CL2 Linker |
Synonyms | CL2 Linker |
CAS | 2270986-66-6 |
Molecular Formula | C68H103N11O22 |
Density | 1.26±0.1 g/cm3(Predicted) |
pKa | 12.65±0.10(Predicted) |
biological activity | CL2 Linker is a cleavable linker of ADC molecules. Almost equivalent drug replacement (~ 6), cell binding (Kd ~ 1.2 nM), cytotoxicity (IC50~2.2 nM) CL2-SN-38 and CL2A-SN-38 and in vitro serum stability (t1/2-20 hours). |