Name | Fosamprenavir calcium |
Synonyms | Lexiva Telzir GW-433908 GW-433908G FOSAMPRENAVIR Fosamprenavir calcium fosamprenavir calcium Fosamprenavir calcium salt FOSAMPRENAVIR, CALCIUM SALT Calcium [(3S)-oxolan-3-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-1-phenyl-3-phosphonatooxy-butan-2-yl]carbamate calcium [(3s)-oxolan-3-yl] n-[(2s,3r)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-1-phenyl-3-phosphonatooxy-butan-2-yl]carbamate calcium (2R,3S)-1-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-4-phenyl-3-({[(3S)-tetrahydrofuran-3-yloxy]carbonyl}amino)butan-2-yl phosphate |
CAS | 226700-81-8 |
EINECS | 607-123-4 |
InChI | InChI=1/C25H36N3O9PS.Ca/c1-18(2)15-28(39(33,34)22-10-8-20(26)9-11-22)16-24(37-38(30,31)32)23(14-19-6-4-3-5-7-19)27-25(29)36-21-12-13-35-17-21;/h3-11,18,21,23-24H,12-17,26H2,1-2H3,(H,27,29)(H2,30,31,32);/q;+2/t21-,23-,24+;/m0./s1 |
Molecular Formula | C25H34CaN3O9PS |
Molar Mass | 623.668921 |
Melting Point | 282-2840C |
Solubility | Aqueous Acid (Slightly), DMF (Slightly) |
Appearance | Solid |
Color | White to Off-White |
Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
In vitro study | The calcium salt of the prodrug, Fosamprenavir Calcium Salt (GW433908G), is selected for further investigation, as it appears to offer the greatest potential for the development of new drug formulations. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.603 ml | 8.017 ml | 16.034 ml |
5 mM | 0.321 ml | 1.603 ml | 3.207 ml |
10 mM | 0.16 ml | 0.802 ml | 1.603 ml |
5 mM | 0.032 ml | 0.16 ml | 0.321 ml |
biological activity | Fosamprenavir are amprenavir prodrugs. Amprenavir are proteasome inhibitors and antiretroviral drugs. Fosamprenavir can be used to treat HIV-1 infections. |
target | HIV |