225937-10-0
(+)-Catechin Hydrate
CAS: 225937-10-0
Molecular Formula: C15H16O7
225937-10-0 - Names and Identifiers
225937-10-0 - Physico-chemical Properties
| Molecular Formula | C15H16O7 |
| Molar Mass | 308.29 |
| Melting Point | 175-177°C (anhydrous)(lit.) |
| Boling Point | 630.4℃ at760mmHg |
| Specific Rotation(α) | 26 º (C=1 IN H2O) |
| Solubility | ethanol: soluble50mg/mL |
| Appearance | powder |
| Color | yellow to yellow with tan cast |
| Merck | 13,1912 |
| BRN | 3595244 |
| Storage Condition | 2-8°C |
| MDL | MFCD00150865 |
| Use | Flavonoid antioxidants, from plants, free radical scavengers, prevent free radicals from causing damage to various biological systems. |
| In vitro study | (+)-Catechin exhibits >95% inhibitory activity at 70 μg/mL against cyclooxygenase-1 (COX-1) with an IC 50 of 1.4 μM. A dose-dependent reduction in color is observed after 24 hours of treatment with (+)-Catechin, and 54.76% of the cells are dead at the highest concentration of (+)-Catechin tested (160 μg/mL) whereas the IC 50 of (+)-Catechin is achieved at 127.62 μg/mL (+)-Catechin. A dose- and time-dependent increase in the induction of apoptosis is observed when MCF-7 cells are treated with (+)-Catechin. When compare to the control cells at 24 hours, 40.7 and 41.16% of the cells treated with 150 μg/mL and 300 μg/mL (+)-Catechin, respectively, undergo apoptosis. The expression levels of Caspase-3 , -8 , and -9 and p53 in MCF-7 cells treated with 150 μg/mL (+)-Catechin for 24 h increase by 5.81, 1.42, 3.29, and 2.68 fold, respectively, as compare to the levels in untreated control cells. |
| In vivo study | Animals treated with (+)-Catechin at the lowest tested dose, i.e., 50 mg/kg, p.o. have spent comparatively more time in exploring the novel object in the choice trial, however, the difference is not statistically significant. (+)-Catechin prevents the time-induced episodic memory deficits in a dose-dependent manner, the most effective being 200 mg/kg, p.o.. Treatment with (+)-Catechin prevents the rise in MPO level compare to DOX alone treatment group (21.98±9.44 and 36.76±4.39% in the hippocampus and the frontal cortex respectively). |
225937-10-0 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 8-10-23 |
| HS Code | 29329990 |
225937-10-0 - Reference
| Reference Show more | 1. [IF=4.36] Mingliang Gao et al."Evaluation of VEGF mediated pro-angiogenic and hemostatic effects and chemical marker investigation for Typhae Pollen and its processed product."J Ethnopharmacol. 2021 Mar;268:113591 |
225937-10-0 - Reference Information
| biological activity | ( )-Catechin hydrate inhibits cyclooxygenase-1 (COX-1) , IC50 is 1.4 μM. |
| target | COX-1 1.4 μM (IC 50 ) |
| in vitro study | (+)-Catechin exhibits >95% inhibitory activity at 70 μg/mL against cyclooxygenase-1 (COX-1) with an IC 50 of 1.4 μ M. A pose-dependent reduction in color is observed after 24 hours of treatment with (+)-Catechin, and 54.76% of the cells are dead at the highest concentration of (+)-Catechin tested (160 μg/mL) whereas the IC 50 of (+)-Catechin is achieved at 127.62 μg/mL (+)-Catechin. A pose-and time-dependent increase in the induction of apoptosis is observed when MCF-7 cells are treated with (+)-Catechin. When compare to the control cells at 24 hours, 40.7 and 41.16% of the cells treated with 150 μg/mL and 300 μg/mL (+)-Catechin, respectively, undergo apoptosis. The expression levels of Caspase-3 , -8 , and -9 and p53 in MCF-7 cells treated with 150 μg/mL (+)-Catechin for 24 h increase by 5.81, 1.42, 3.29, and 2.68 fold, respectively, as compare to the levels in untreated control cells. |
| in vivo study | Animals treated with (+)-Catechin at the lowest examined dose, I. e., 50 mg/kg, p.o. have spent comparatively more time in exploring the novel object in the choice, however, the difference is not statistically significant. (+)-Catechin prevents the time-induced episodic memory deficits in a dose-dependent manner, the most effective being 200 mg/kg, P. o .. Treatment with (+)-Catechin prevents the rise in MPO level compare to DOX alone treatment group (21.98±9.44 and 36.76±4.39% in the hippocampus and the frontal cortex respectively). |
| use | flavonoid antioxidants, from plants, free radical scavengers, prevent free radical damage to various biological systems. |
Last Update：2024-04-09 21:32:00
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Product Name: (+)-Catechin hydrate Visit Supplier Webpage Request for quotationCAS: 225937-10-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: (+)-Catechin hydrate Visit Supplier Webpage Request for quotationCAS: 225937-10-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: (+)-Catechin hydrate Visit Supplier Webpage Request for quotationCAS: 225937-10-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: (+)-Catechin Hydrate Visit Supplier Webpage Request for quotationCAS: 225937-10-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
225937-10-0
4,6-Dihydroxy-2-methylthio pyrimidine
2-氰基苯胺盐酸盐
C.I.Acid Red 70
2,4-Dichlorophenoxyacetic Acid-13C6
3,6-DICHLORO-1-BENZOTHIOPHENE-2-CARBONYL CHLORIDE
2(3H)-Furanone, dihydro-3-[(R)-hydroxyphenylmethyl]-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (3R,4R)-
Mesna Impurity 5(Mesna EP Impurity E)
尼可地尔杂质P0Z9
4,6-Dihydroxy-2-methylthio pyrimidine
2-氰基苯胺盐酸盐
C.I.Acid Red 70
2,4-Dichlorophenoxyacetic Acid-13C6
3,6-DICHLORO-1-BENZOTHIOPHENE-2-CARBONYL CHLORIDE
2(3H)-Furanone, dihydro-3-[(R)-hydroxyphenylmethyl]-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (3R,4R)-
Mesna Impurity 5(Mesna EP Impurity E)
尼可地尔杂质P0Z9