Name | FM479 |
Synonyms | FM479 2-Propenamide, 2-cyano-3-[5-(1-cyclohexyl-1,6-dihydro-6-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)-2-furanyl]-N,N-dimethyl- |
CAS | 2226521-64-6 |
Molecular Formula | C25H26N6O2 |
Molar Mass | 442.51 |
Storage Condition | -20℃ |
In vitro study | FM-479 is the inactive control of FM-381, the concentration used in assays is similar. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 0 ml | 0 ml | 0 ml |
5 mM | 0 ml | 0 ml | 0 ml |
10 mM | 0 ml | 0 ml | 0 ml |
5 mM | 0 ml | 0 ml | 0 ml |
biological activity | FM-479 is a FM-381 (HY-102046) negative control that is inactive against JAK3 or other kinases. FM-381 is a potent covalently reversible inhibitor of JAK3 targeting a unique cys909. For JAK3, FM-381 had an IC50 of 127 pM selectivity, 410-fold, 2700-fold and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively. |