Name | LY2794193 |
Synonyms | LY2794193 Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-4-[(3-methoxybenzoyl)amino]-, (1S,2S,4S,5R,6S)- |
CAS | 2173037-97-1 |
Molecular Formula | C16H18N2O6 |
Molar Mass | 334.32 |
Density | 1.50±0.1 g/cm3(Predicted) |
Boling Point | 598.6±50.0 °C(Predicted) |
pKa | 1.78±0.60(Predicted) |
In vitro study | LY2794193 exhihits inhibition of spontaneous Ca 2+ oscillations in cultured rat cortical neurons with an EC 50 of 43.6 nM. In the rat cortical neuron Ca 2+ oscillation assay, LY2794193 exhibits a biphasic inhibition of spontaneous Ca 2+ transients (high affinity EC 50 =0.44 nM; 48% of the total agonist response; low affinity EC 50 =43.6 nM; 52% of the total agonist response) with combined maximal agonist efficacy (E max ) of 66%. |