2.6-二氟苯硼酸频呢醇酯

2.6-二氟苯硼酸频呢醇酯 - Names and Identifiers

Name	2,6-DifluoroBenzeneBoronicacid,pinacolester
Synonyms	2,6-DifluoroBenzeneBoronicacid,picolester 2,6-DifluoroBenzeneBoronicacid,pinacolester 2,6-Difluorophenylboronic acid, pinacol ester 2-(2,6-Difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaBorolane 2-(2,6-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborola... 1,3,2-Dioxaborolane, 2-(2,6-difluorophenyl)-4,4,5,5-tetramethyl- 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-difluorobenzene 3-hydroxy-2,3-dimethylbutan-2-yl hydrogen (2,6-difluorophenyl)boronate
CAS	863868-37-5

2.6-二氟苯硼酸频呢醇酯 - Physico-chemical Properties

Molecular Formula	C12H15BF2O2
Molar Mass	240.05
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C

2.6-二氟苯硼酸频呢醇酯 - Risk and Safety

Hazard Symbols

Xi - Irritant

2.6-二氟苯硼酸频呢醇酯 - Reference Information

use

2, 6-difluorophenylborate pinacol ester is a carboxylate derivative, which is a widely used drug intermediate.

preparation

in a 500 mL three-mouth bottle, add 10 g 1, 3-difluoro-2-bromobenzene, 17 g isopropanol pinacol borate and 210 mL
dry tetrahydrofuran, insert the thermometer, pump off the air, fill with nitrogen for protection, cool down to -78 ℃, then slowly add 36. 1 mL n-butyl lithium with a syringe, after adding, react at -78
℃ for 5 min. Slowly raise to room temperature for 20 min, adjust to pH = 6~7 with 2 M hydrochloric acid, stir for 30
min, stand still, delaminate, separate the organic layer, extract the water layer with ethyl acetate, and merge the organic layer. The organic layer is dried with anhydrous sodium sulfate, evaporated to remove the solvent, and passed through a silica gel chromatography column to obtain 10 g of colorless oily liquid. The yield was
82.7%.

Last Update：2024-04-09 02:00:07