2-环己基-2-羟基-2-苯基乙酸甲酯
Methyl cyclohexylphenylglycolate
CAS: 10399-13-0
Molecular Formula: C15H20O3
2-环己基-2-羟基-2-苯基乙酸甲酯 - Names and Identifiers
2-环己基-2-羟基-2-苯基乙酸甲酯 - Physico-chemical Properties
| Molecular Formula | C15H20O3 |
| Molar Mass | 248.32 |
| Density | 1.130±0.06 g/cm3(Predicted) |
| Melting Point | 40 °C |
| Boling Point | 170-175 °C(Press: 9 Torr) |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | White to Off-White Waxy to |
| pKa | 12.19±0.29(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Use | Application 2-cyclohexyl-2-hydroxyphenylacetic acid methyl ester is an organic intermediate, it has been reported that it can be prepared from bromocyclohexane and 2-oxo-2-phenylacetic acid -2-methyl ester or benzoyl formate and cyclohexene as starting materials, and can be used in laboratory research and development process and chemical production process. |
2-环己基-2-羟基-2-苯基乙酸甲酯 - Risk and Safety
| HS Code | 2918191350 |
2-环己基-2-羟基-2-苯基乙酸甲酯 - Upstream Downstream Industry
2-环己基-2-羟基-2-苯基乙酸甲酯 - Preparation
Under nitrogen, bromocyclohexane (5.96g,36.55 mmol) is added dropwise to the anhydrous ether mixture of magnesium chips (0.87g,36.25 mmol) and iodine crystals, first 1 mL is added, and the rest is added after the start of the reaction, while maintaining mild reflux. Stir the mixture at room temperature until all magnesium is dissolved (1 hour). The cyclohexylmagnesium bromide solution thus obtained was cooled to 0°C. Tetrahydrofuran (20mL) solution of 2-oxo-2-phenylacetic acid (3.0g,18.29mmol) was added dropwise. The reaction mixture was allowed to reach room temperature and stirred for 2 hours. It was then cooled to 0°C, quenched by slowly adding a saturated ammonium chloride solution and extracted with ethyl acetate. The organic layer was washed with water and brine, dried by Na2SO4, and the solvent was evaporated under reduced pressure to give a crude residue, which was purified by silica gel column chromatography (1.5% ethyl acetate in petroleum ether) to obtain yellow viscous 2-cyclohexyl-2-hydroxyphenylacetate methyl, liquid (2.6g,57%).
Last Update：2024-04-10 22:29:15
2-环己基-2-羟基-2-苯基乙酸甲酯 - Reference Information
| application | 2-cyclohexyl -2-hydroxyphenylacetic acid methyl ester is an organic intermediate. It is reported in the literature that it can be prepared from bromocyclohexane and 2-oxo-2-phenylacetic acid -2-methyl ester or benzoformate and cyclohexene as starting materials, it can be used in laboratory research and development process and chemical production process. |
| Preparation | Under nitrogen, bromocyclohexane (5.96g,36.55 mmol) is added dropwise to the anhydrous ether mixture of magnesium chips (0.87g,36.25 mmol) and iodine crystals, 1 mL is added first, and the rest is added after the reaction starts while maintaining mild reflux. Stir the mixture at room temperature until all magnesium is dissolved (1 hour). The cyclohexylmagnesium bromide solution thus obtained was cooled to 0°C. Tetrahydrofuran (20mL) solution of 2-oxo-2-phenylacetic acid (3.0g,18.29mmol) was added dropwise. The reaction mixture was allowed to reach room temperature and stirred for 2 hours. It was then cooled to 0°C, quenched by slowly adding a saturated ammonium chloride solution and extracted with ethyl acetate. The organic layer was washed with water and salt water, dried by Na2SO4, and the solvent was evaporated under reduced pressure to give a crude residue, which was purified by silica gel column chromatography (ethyl 1.5% acetate in petroleum ether) to obtain yellow viscous 2-cyclohexyl-2-hydroxyphenylacetate methyl, liquid (2.6g,57%). |
Last Update：2024-04-09 21:11:58
Supplier List
Multiple SpecificationsSpot supply
Product Name: Methyl 2-cyclohexyl-2-hydroxyphenylacetate Visit Supplier Webpage Request for quotationCAS: 10399-13-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: a-Cyclohexyl-Mandelic Acid Methyl Ester Visit Supplier Webpage Request for quotationCAS: 10399-13-0
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: Oxybutynin Related Compound B Visit Supplier Webpage Request for quotationCAS: 10399-13-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: Cyclohexylmandelic Acid Methyl Ester Visit Supplier Webpage Request for quotation
CAS: 10399-13-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 10399-13-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Multiple SpecificationsSpot supply
Product Name: Methyl 2-cyclohexyl-2-hydroxyphenylacetate Visit Supplier Webpage Request for quotationCAS: 10399-13-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: a-Cyclohexyl-Mandelic Acid Methyl Ester Visit Supplier Webpage Request for quotationCAS: 10399-13-0
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: Oxybutynin Related Compound B Visit Supplier Webpage Request for quotationCAS: 10399-13-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Product Name: Cyclohexylmandelic Acid Methyl Ester Visit Supplier Webpage Request for quotation
CAS: 10399-13-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 10399-13-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
2-环己基-2-羟基-2-苯基乙酸甲酯
4-Acetoxy-3-Methoxycinnamic Acid
3-hexadecyloxy-propan-1-ol ether
双酚A(2,3-二羟丙基)甘油醚
反式-1,4-二溴-2-丁烯-D6
3-苯甲酰吡啶
4-Acetoxy-3-Methoxycinnamic Acid
3-hexadecyloxy-propan-1-ol ether
双酚A(2,3-二羟丙基)甘油醚
反式-1,4-二溴-2-丁烯-D6
3-苯甲酰吡啶
Raw Materials for 2-环己基-2-羟基-2-苯基乙酸甲酯