2-溴-6-吡啶硼酸频呐醇酯

2-溴-6-吡啶硼酸频呐醇酯 - Names and Identifiers

Name	6-Bromopyridine-2-boronic acid pinacol ester
Synonyms	6-Bromopyridine- 6-Bromopyridine-2-boronic... 6-Bromopyridine-2-boronic acid picol ester 6-Bromopyridine-2-boronic acid pinacol ester 2-Bromopyridine-6-boronic acid pinacol ester 6-BROMOPYRIDINE-2-BORONIC ACID PINACOL ESTER 2-broMo-6-(tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine 2-BROMO-6-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 2-bromo-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
CAS	651358-83-7
EINECS	145-896-5
InChI	InChI=1/C11H15BBrNO2/c1-10(2)11(3,4)16-12(15-10)8-6-5-7-9(13)14-8/h5-7H,1-4H3

2-溴-6-吡啶硼酸频呐醇酯 - Physico-chemical Properties

Molecular Formula	C11H15BBrNO2
Molar Mass	283.96
Density	1.34±0.1 g/cm3(Predicted)
Melting Point	125-127℃
Boling Point	354.7±27.0 °C(Predicted)
Flash Point	168.3°C
Solubility	soluble in Toluene
Vapor Presure	6.71E-05mmHg at 25°C
Appearance	Solid
Color	White to Almost white
pKa	0.82±0.19(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.527
MDL	MFCD06796177

2-溴-6-吡啶硼酸频呐醇酯 - Risk and Safety

Hazard Symbols	T - Toxic
Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R36 - Irritating to the eyes R25 - Toxic if swallowed
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN2811

2-溴-6-吡啶硼酸频呐醇酯 - Introduction

6-Bromopyridine-2-boronic acid pinacol ester is an organic compound whose main properties include the following:

1. Appearance and properties: 6-Bromopyridine-2-boronic acid pinacol ester is usually a colorless to light yellow solid.

2. Solubility: It is soluble in some organic solvents, such as dichloromethane, dimethyl sulfoxide and tetrahydrofuran.

3. Stability: It can be stored stably at room temperature.

6-Bromopyridine-2-boronic acid pinacol ester has a wide range of applications in organic synthesis:

1. Catalyst: It can be used as a ligand for palladium-catalyzed reactions, such as Suzuki coupling reactions, to help build carbon-carbon bonds.

2. Intermediate: It can be used as an intermediate for the synthesis of various pesticides, medicines and functional organic molecules.

Method of preparing 6-Bromopyridine-2-boronic acid pinacol ester:

The common preparation method is obtained by the reaction of 6-bromopyrimidine and 2-boronic acid pinacol. The reaction is generally carried out in an organic solvent under palladium catalysis and at an appropriate temperature.

About safety information:

The security information of 6-Bromopyridine-2-boronic acid pinacol ester is as follows:

1. Irritating to skin and eyes, contact with skin and eyes should be avoided.

2. Take appropriate safety measures during handling and storage, such as wearing gloves and goggles.

3. During the operation, attention should be paid to prevent inhalation and intake to avoid poisoning.

4. When handling the compound, follow safe operating procedures and ensure proper ventilation conditions.

It should be noted that this is only general safety information, and specific safety operation measures should be evaluated according to specific conditions and follow relevant regulations and guidelines.

Last Update：2024-04-10 22:41:03