2-氯甲酰基吡啶盐酸盐
Picolinoyl chloride hydrochloride
CAS: 39901-94-5
Molecular Formula: C6H5Cl2NO
2-氯甲酰基吡啶盐酸盐 - Names and Identifiers
2-氯甲酰基吡啶盐酸盐 - Physico-chemical Properties
| Molecular Formula | C6H5Cl2NO |
| Molar Mass | 178.02 |
| Melting Point | 123°C |
| Boling Point | 204.1°C at 760 mmHg |
| Flash Point | 77.3°C |
| Vapor Presure | 0.268mmHg at 25°C |
| Appearance | Brown solid |
| Color | White to Gray to Red |
| Storage Condition | Inert atmosphere,2-8°C |
| MDL | MFCD00060193 |
2-氯甲酰基吡啶盐酸盐 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R34 - Causes burns R36 - Irritating to the eyes R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | 1759 |
| Hazard Class | 8 |
| Packing Group | II |
2-氯甲酰基吡啶盐酸盐 - Introduction
Picolinoyl chloride hydrochloride, chemical formula C7H7Cl2NO, is an organic compound. It is a white or off-white solid with a pungent odor. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: Picolinoyl chloride hydrochloride appear as crystals or crystalline powder, soluble in alcohol and some organic solvents, insoluble in water.
-Melting point: about 60°C to 65°C.
-Density: about 1.37g/cm³.
-toxicity: belong to organic chlorine compounds, has a certain toxicity.
Use:
Picolinoyl chloride hydrochloride has certain uses in the field of organic synthesis, commonly used in the following aspects:
-as an acylating reagent: it can be used in the acylation reaction to react with ketones, aldehydes, amines, etc. to generate the corresponding acylated products.
-As a reagent in the protecting group reaction: In organic synthesis, it can be used as a protecting group reagent for chlorination reaction to protect amine or alcohol groups, thereby preventing non-selective reactions during the synthesis process.
Preparation Method:
The preparation of Picolinoyl chloride hydrochloride can be carried out by the following steps:
1. Pyridine-2-carboxylic acid is dissolved in anhydrous hydrogen chloride, and nitrous acid is added to react to generate nitroso compound.
2. The nitroso compound obtained in the first step is dissolved in an alkylene chloride and reacted to generate a Picolinoyl chloride hydrochloride.
3. The prepared product is purified by freeze crystallization or vacuum drying to obtain the final product.
Safety Information:
- Picolinoyl chloride hydrochloride belongs to organic chlorine compounds, has certain toxicity. Safety precautions should be taken during use to avoid contact with skin and inhalation of gas.
-Use should comply with the laboratory's chemical operating specifications to avoid the release of toxic gases and other dangerous situations.
-Storage should be sealed and kept away from fire and heat sources to prevent contact with oxidants.
Nature:
-Appearance: Picolinoyl chloride hydrochloride appear as crystals or crystalline powder, soluble in alcohol and some organic solvents, insoluble in water.
-Melting point: about 60°C to 65°C.
-Density: about 1.37g/cm³.
-toxicity: belong to organic chlorine compounds, has a certain toxicity.
Use:
Picolinoyl chloride hydrochloride has certain uses in the field of organic synthesis, commonly used in the following aspects:
-as an acylating reagent: it can be used in the acylation reaction to react with ketones, aldehydes, amines, etc. to generate the corresponding acylated products.
-As a reagent in the protecting group reaction: In organic synthesis, it can be used as a protecting group reagent for chlorination reaction to protect amine or alcohol groups, thereby preventing non-selective reactions during the synthesis process.
Preparation Method:
The preparation of Picolinoyl chloride hydrochloride can be carried out by the following steps:
1. Pyridine-2-carboxylic acid is dissolved in anhydrous hydrogen chloride, and nitrous acid is added to react to generate nitroso compound.
2. The nitroso compound obtained in the first step is dissolved in an alkylene chloride and reacted to generate a Picolinoyl chloride hydrochloride.
3. The prepared product is purified by freeze crystallization or vacuum drying to obtain the final product.
Safety Information:
- Picolinoyl chloride hydrochloride belongs to organic chlorine compounds, has certain toxicity. Safety precautions should be taken during use to avoid contact with skin and inhalation of gas.
-Use should comply with the laboratory's chemical operating specifications to avoid the release of toxic gases and other dangerous situations.
-Storage should be sealed and kept away from fire and heat sources to prevent contact with oxidants.
Last Update：2024-04-10 22:29:15
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View History
2-氯甲酰基吡啶盐酸盐
Inlet check valve (complete assembly)
EC 3.2.1.18 TYPE II
POLY(DIMETHYLSILOXANE-CO-ETHYLENE OXIDE), AB BLOCK COPOLYMER
二甲氨基丙酰胺基 PCA 聚二甲基硅氧烷
N-[4-硝基-3-(三氟甲基)苯基]-(2S)-3-[4-(乙酰基氨基)苯氧基]-2-羟基-2-甲基丙酰胺
uridine 5'-(phosphoimidazolate)
(3-Ethyladamantan-1-yl)thiocarbamic acid S-benzyl ester
Strospeside 16-formate
(S)-2-((((9H-芴-9-基)甲氧基)羰基)氨基)-2,4-二甲基戊酸
Inlet check valve (complete assembly)
EC 3.2.1.18 TYPE II
POLY(DIMETHYLSILOXANE-CO-ETHYLENE OXIDE), AB BLOCK COPOLYMER
二甲氨基丙酰胺基 PCA 聚二甲基硅氧烷
N-[4-硝基-3-(三氟甲基)苯基]-(2S)-3-[4-(乙酰基氨基)苯氧基]-2-羟基-2-甲基丙酰胺
uridine 5'-(phosphoimidazolate)
(3-Ethyladamantan-1-yl)thiocarbamic acid S-benzyl ester
Strospeside 16-formate
(S)-2-((((9H-芴-9-基)甲氧基)羰基)氨基)-2,4-二甲基戊酸