2-氯吡啶-3-硼酸频哪醇酯

2-氯吡啶-3-硼酸频哪醇酯 - Names and Identifiers

Name	2-Chloropyridine-3-boronic acid pinacol ester
Synonyms	2-Chloro-3-(4 2]dioxaborolan-2-yl)-pyridine 2-CHLOROPYRIDINE-3-BORONIC ACID PINACOL ESTER 2-Chloropyridine-3-boronic acid pinacol ester 2-CHLOROPYRIDIN-3-YLBORONIC ACID PINACOL ESTER 2-chloro-3-(tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine 2-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 2-CHLORO-3-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE 2-[(2-Chloro)pyridin-3-yl]-4,4',5,5'-tetramethyl-1,3-dioxaborolane pyridine, 2-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 2-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, 2-(2-Chloropyridin-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CAS	452972-11-1
InChI	InChI=1/C11H15BClNO2/c1-10(2)11(3,4)16-12(15-10)8-6-5-7-14-9(8)13/h5-7H,1-4H3

2-氯吡啶-3-硼酸频哪醇酯 - Physico-chemical Properties

Molecular Formula	C11H15BClNO2
Molar Mass	239.51
Density	1.14±0.1 g/cm3(Predicted)
Melting Point	34-38°C
Boling Point	335.1±27.0 °C(Predicted)
Flash Point	156.4°C
Vapor Presure	0.000239mmHg at 25°C
Appearance	Crystalline Powder
Color	White to yellow to light brown
pKa	-0.27±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.505
MDL	MFCD04039873

2-氯吡啶-3-硼酸频哪醇酯 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves.
WGK Germany	3
HS Code	29333999
Hazard Class	IRRITANT

2-氯吡啶-3-硼酸频哪醇酯 - Introduction

2-Chloropyridine-3-boronic acid pinacol ester is an organic compound with the chemical formula C12H15BClNO2.

In terms of nature, it is a solid with a white to light yellow crystal appearance. It can be dissolved in some organic solvents such as dimethyl sulfoxide (DMSO), ethanol and ether.

2-Chloropyridine-3-boronic acid pinacol ester has important applications in the field of organic synthesis. It is often used as a starting material for cross-coupling reactions in organometallic chemistry. Through this compound, target compounds containing pyridine and boronic acid functional groups can be prepared, and then used in the fields of drug research and development, material science and pesticide synthesis.

in terms of preparation method, the most commonly used method is to first condense 2-chloro-pyridine with trimethylboronic acid to obtain 2-chloro-pyridine-3-boronic acid ester, and then react with pinacol to obtain 2-chloropyridine-3-boronic acid pinacol ester.

Regarding safety information, 2-Chloropyridine-3-boronic acid pinacol ester belongs to organic matter and has certain toxicity. It is necessary to take appropriate safety measures during operation, such as wearing chemical protective gloves and goggles, and ensure that the operation is carried out in a well-ventilated place. At the same time, should be away from fire and high temperature, storage should be kept in a dry, cool place.

In general, 2-Chloropyridine-3-boronic acid pinacol ester is an important compound commonly used in organic synthesis and has a wide range of applications. But be sure to pay attention to safety during use.

Last Update：2024-04-10 22:30:50