2-氯-4-吡啶硼酸频呐醇酯

2-氯-4-吡啶硼酸频呐醇酯 - Names and Identifiers

Name	2-Chloropyridine-4-boronic acid pinacol ester
Synonyms	2-Chloro-4-(4 2-CHLOROPYRIDINE-4-BORONIC PINACOL ESTER 2-Chloropyridine-4-boronic acid pinacol ester 2-CHLOROPYRIDIN-4-YLBORONIC ACID PINACOL ESTER 2-CHLOROPYRIDINE-4-BORONIC ACID, PINACOL ESTER 2-chloro-4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine 2-[4-(2-chloro)pyridine]-4,4,5,5-tetraMethyl-1,3-dioxaborolane 2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 2-CHLORO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABROLAN-2-YL)-PYRIDINE 2-CHLORO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE
CAS	458532-84-8
InChI	InChI=1/C11H15BClNO2/c1-10(2)11(3,4)16-12(15-10)8-5-6-14-9(13)7-8/h5-7H,1-4H3

2-氯-4-吡啶硼酸频呐醇酯 - Physico-chemical Properties

Molecular Formula	C11H15BClNO2
Molar Mass	239.51
Density	1.14±0.1 g/cm3(Predicted)
Melting Point	64.7-64.8°C
Boling Point	338.2±27.0 °C(Predicted)
Flash Point	158.3°C
Vapor Presure	0.000196mmHg at 25°C
Appearance	powder to crystal
Color	White to Light yellow to Light orange
pKa	-0.58±0.10(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Refractive Index	1.505
MDL	MFCD04039870

2-氯-4-吡啶硼酸频呐醇酯 - Risk and Safety

Risk Codes	R25 - Toxic if swallowed R36 - Irritating to the eyes
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	UN 2811 6.1 / PGIII
Hazard Class	IRRITANT

2-氯-4-吡啶硼酸频呐醇酯 - Introduction

2-Chloropyridine-4-boronic acid pinacol ester is an organic compound with the chemical formula C12H15BClNO2. It is a white solid, relatively stable at room temperature. The following is an introduction to the nature, use, preparation and safety information of 2-Chloropyridine-4-boronic acid pinacol ester:

Nature:
-Appearance: White solid
-Molecular weight: 254.52g/mol
-Melting point: about 75-80°C
-Solubility: 2-Chloropyridine-4-boronic acid pinacol ester is soluble in organic solvents such as chloroform, methanol and dichloromethane.

Use:
- 2-Chloropyridine-4-boronic acid pinacol ester is an important intermediate in organic synthesis, which is used to synthesize various organic compounds containing boron functional groups.
-It is one of the ligands in metal-catalyzed reactions and is widely used in C- C bond formation reactions, carbonylation reactions, cross-coupling reactions and functional reactions of aromatic hydrocarbons.

Preparation Method:
The preparation method of 2-Chloropyridine-4-boronic acid pinacol ester can be achieved by the reaction of pyridine-4-boronic acid and 2-chloropyridine. The specific synthesis process needs to be carried out under an inert atmosphere.

Safety Information:
2-Chloropyridine-4-boronic acid pinacol ester generally has no obvious harm to human body and environment when used and handled correctly. However, as an organic compound, it may have irritating effects on the eyes, skin and respiratory system. Take proper precautions during handling and storage to avoid contact with skin or inhalation of vapors. In case of accidental contact, rinse immediately with water and seek medical help. During use, please make sure to work in a well-ventilated place and operate in accordance with appropriate laboratory practices.

Last Update：2024-04-10 22:29:15