2-氯-4-三氟甲基-5-溴嘧啶

2-氯-4-三氟甲基-5-溴嘧啶 - Names and Identifiers

Name	5-bromo-2-chloro-4-(trifluoromethyl)pyridine
Synonyms	5-bromo-2-chloro-4-(trifluoromethyl)pyridine 5-BROMO-2-CHLORO-4-(TRIFLUOROMETHYL)PYRIDINE 2-chloro-5-bromo-4-(trifluoromethyl)pyrimidine 5-BROMO-2-CHLORO-4-(TRIFLUOROMETHYL)PYRIMIDINE Pyridine, 5-broMo-2-chloro-4-(trifluoroMethyl)- 5-Bromo-2-chloro-4-(trifluoromethyl)-1,3-diazine Pyrimidine, 5-bromo-2-chloro-4-(trifluoromethyl)-
CAS	823221-93-8 785777-92-6
InChI	InChI=1/C6H2BrClF3N/c7-4-2-12-5(8)1-3(4)6(9,10)11/h1-2H

2-氯-4-三氟甲基-5-溴嘧啶 - Physico-chemical Properties

Molecular Formula	C6H2BrClF3N
Molar Mass	260.44
Density	1.813 g/cm3
Melting Point	11-13 °C
Boling Point	80-81 °C(Press: 16 Torr)
Flash Point	82.4°C
Vapor Presure	0.249mmHg at 25°C
pKa	-3.73±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.492

2-氯-4-三氟甲基-5-溴嘧啶 - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Class	IRRITANT

2-氯-4-三氟甲基-5-溴嘧啶 - Introduction

5-bromo-2-chloro-4-(trifluoromethyl)pyridine is an organic compound whose chemical formula is C6H2BrClF3N. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: 5-bromo-2-chroo-4-(trifluoromethyl)pyridine is a colorless to pale yellow solid.
-Melting point: about 57-59 degrees Celsius.
-Boiling point: about 179-182 degrees Celsius.
-Density: about 1.77g/cm3.

Use:
- 5-bromo-2-chloro-4-(trifluoromethyl)pyridine are commonly used as catalysts and intermediates in organic synthesis reactions.
-It can be used to prepare pharmaceutical compounds, pesticides and heterocyclic compounds.

Preparation Method:
5-bromo-2-chloro-4-(trifluoromethyl)pyridine can be prepared by the following steps:
1. react 2-chloro -4-trifluoromethyl pyridine with nitrosyl chloride to generate 2-nitroso -4-trifluoromethyl pyridine.
2. react 2-nitroso -4-trifluoromethyl pyridine with bromine to generate 5-bromo -2-nitroso -4-trifluoromethyl pyridine.
3.5-bromo-2-nitroso -4-trifluoromethylpyridine is reacted with sodium sulfite to generate 5-bromo-2-chloro-4-(trifluoromethyl)pyridine.

Safety Information:
- 5-bromo-2-chloro-4-(trifluoromethyl)pyridine is an organic compound that is irritating and dangerous.
-Appropriate protective measures should be taken during handling and storage, such as wearing gloves and protective clothing.
-Avoid contact with skin and eyes. If you do, rinse immediately with plenty of water.
-Should not inhale its dust or vapor, should be used in a well-ventilated place.
-Store in a sealed container, away from fire and oxidizing agents.

Last Update：2024-04-09 02:00:48