2-氨基-3-溴-5-硝基苯甲腈
2-Cyano-4-nitro-6-bromoaniline
CAS: 17601-94-4
Molecular Formula: C7H4BrN3O2
2-氨基-3-溴-5-硝基苯甲腈 - Names and Identifiers
2-氨基-3-溴-5-硝基苯甲腈 - Physico-chemical Properties
| Molecular Formula | C7H4BrN3O2 |
| Molar Mass | 242.03 |
| Density | 1.8856 (rough estimate) |
| Melting Point | 180-185°C(lit.) |
| Boling Point | 374.8±42.0 °C(Predicted) |
| Flash Point | 89.2°C |
| Vapor Presure | 0.115mmHg at 25°C |
| Appearance | Yellow powder |
| Color | Light orange to Yellow to Green |
| pKa | -4.23±0.20(Predicted) |
| Storage Condition | Room Temprature |
| Refractive Index | 1.6200 (estimate) |
| MDL | MFCD00054185 |
| Physical and Chemical Properties | Melting point 180-185°C |
| Use | Mainly used for the synthesis of disperse dyes |
2-氨基-3-溴-5-硝基苯甲腈 - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/39 - S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29269090 |
| Hazard Note | Irritant |
| Hazard Class | 6.1 |
| Packing Group | III |
2-氨基-3-溴-5-硝基苯甲腈 - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| application | 2-cyano-4-nitro-6-bromoaniline is a very important disperse dye intermediate and an important raw material for synthesizing disperse dyes such as disperse blue 183. |
| preparation | (1) synthesis of 2-cyano -4-nitroaniline: A1, put 100g of o-chlorobenzonitrile into 333g of sulfuric acid medium, then add mixed acid dropwise, nitrification at 5-10 ℃ to obtain nitrate; The mixed acid is made by mixing HNO3 and H2SO4 in a mass percentage of 0.5:1; a2, the nitrate in step A1 is hydrolyzed by adding water, and then filtered to obtain nitrification material; A3, dissolve the nitrification material in step A2 in 400g of chlorobenzene to obtain a mixed solution of nitrate and chlorine; A4, ammonolysis reaction of nitrate and chlorine mixture in step A3 with liquid ammonia, distillation to recover solvent at 80 ℃ after reaction to the end point; Ammonolysis reaction temperature is 110 ℃, the ammonolysis reaction pressure is 2.6MPa; the end point of the reaction is determined in a liquid chromatography; A5. The solvent in step A4 is filtered and washed to neutral to obtain a wet product product, namely 2-cyano -4-Nitroaniline wet product; the reaction equation in this step (1) is: It can be seen that the sulfuric acid medium essentially acts as a solvent and provides acidic conditions for the reaction, sulfuric acid does not participate in the reaction. (2) Synthesis of 2-cyano -4-nitro -6-bromoaniline: B1, weigh 100g of 2-cyano -4-nitroaniline prepared in step A5 and put it into 20g of sulfuric acid medium, then add hydrogen bromide and 50g hydrogen peroxide dropwise for reaction; B2, after the reaction in step B1 reaches the end point through end point control, filtration was performed to obtain a wet product of 2-cyanide-4-nitro-6-bromoaniline. The reaction equation in this step (2) is: Similarly, the sulfuric acid medium essentially acts as a solvent, providing acidic conditions for the reaction, and sulfuric acid does not participate in the reaction. |
| use | mainly used to synthesize disperse dyes |
Last Update：2024-04-10 22:29:15
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View History
2-氨基-3-溴-5-硝基苯甲腈
2-对甲氧基苯基-2-甲基丙腈
Diethyl (Nitromethyl)phosphonate
4-氨基苯酚磷酸硫代硫酸酯
4-[P-(DIMETHYLAMINO)STYRYL]-1-METHYLPYRIDINIUM IODIDE
烟酰胺核糖氯化物 NR-CL,烟酰胺核糖氯化物
4-(4-溴-2-甲酰基苯基)哌嗪-1-羧酸叔丁酯
N-[2-[(R)-(3-氯苯基)[(3R)-1-[[[(2S)-2-(甲基氨基)-3-[(3R)-四氢-2H-吡喃-3-基]丙基]氨基]羰基]-3-哌啶基]甲氧基]乙基]氨基甲酸甲酯
6,8-DICHLORO-3(2',4'-DICHLOROPHENYL)-4-PHENYLCOUMARIN
3-(4-氯-7H-吡咯并[2,3-d]嘧啶-7-基)吡咯烷-1-甲酸叔丁酯
2-对甲氧基苯基-2-甲基丙腈
Diethyl (Nitromethyl)phosphonate
4-氨基苯酚磷酸硫代硫酸酯
4-[P-(DIMETHYLAMINO)STYRYL]-1-METHYLPYRIDINIUM IODIDE
烟酰胺核糖氯化物 NR-CL,烟酰胺核糖氯化物
4-(4-溴-2-甲酰基苯基)哌嗪-1-羧酸叔丁酯
N-[2-[(R)-(3-氯苯基)[(3R)-1-[[[(2S)-2-(甲基氨基)-3-[(3R)-四氢-2H-吡喃-3-基]丙基]氨基]羰基]-3-哌啶基]甲氧基]乙基]氨基甲酸甲酯
6,8-DICHLORO-3(2',4'-DICHLOROPHENYL)-4-PHENYLCOUMARIN
3-(4-氯-7H-吡咯并[2,3-d]嘧啶-7-基)吡咯烷-1-甲酸叔丁酯