2-氨基-3-(2-氟苯基)丙酸
3-(2-Fluorophenyl)-DL-alanine
CAS: 2629-55-2
Molecular Formula: C9H10FNO2
2-氨基-3-(2-氟苯基)丙酸 - Names and Identifiers
| Name | 3-(2-Fluorophenyl)-DL-alanine |
| Synonyms | h-dl-phe(2-f)-oh H-DL-Phe(2-F)-OH 2-FLUORO-DL-PHENYLAL 2-fluoro-phenylalanin 2-Fluoro-DL-phenylalanine DL-3-(2-Fluorophenyl)alanine 3-(2-Fluorophenyl)-DL-alanine o-FLUORO-DL-PHENYLALANINE extrapure DL-2-F-Phe-OH 2-Fluoro-DL-Phenylalanine DL-2-Amino-3-(2-fluoro-phenyl)-propionic acid |
| CAS | 2629-55-2 |
| EINECS | 220-105-7 |
| InChI | InChI=1/C9H10FNO2/c10-7-4-2-1-3-6(7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13) |
| InChIKey | NYCRCTMDYITATC-UHFFFAOYSA-N |
2-氨基-3-(2-氟苯基)丙酸 - Physico-chemical Properties
| Molecular Formula | C9H10FNO2 |
| Molar Mass | 183.18 |
| Density | 1.1939 (estimate) |
| Melting Point | 243-246°C(lit.) |
| Boling Point | 308.1±32.0 °C(Predicted) |
| BRN | 3201186 |
| pKa | pK1:2.14(＋1);pK2:9.01(0) (25°C) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| MDL | MFCD00004271 |
2-氨基-3-(2-氟苯基)丙酸 - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| UN IDs | 2811 |
| WGK Germany | 3 |
| RTECS | AY6307000 |
| Hazard Note | Harmful |
| Hazard Class | 6.1 |
| Packing Group | III |
2-氨基-3-(2-氟苯基)丙酸 - Introduction
3-(2-Fluorophenyl)-DL-alanine is an organic compound with the chemical formula C9H10FNO2. The following is a detailed description of the properties, uses, preparation methods and safety information of the compound:
Nature:
3-(2-Fluorophenyl)-DL-alanine is a colorless crystalline solid with a slightly sweet taste at room temperature. It is soluble in water and some organic solvents such as ethanol and dichloromethane. It is a compound with stereoisomers, including both the D-isomer and the L-isomer.
Use:
3-(2-Fluorophenyl)-DL-alanine has certain applications in the pharmaceutical industry. It is an unnatural amino acid that can act as a catalyst in the synthesis of organic compounds as a chiral reagent. In addition, it is also used as an intermediate in the synthesis of biologically active compounds, such as synthetic drugs and pesticides.
Method:
The synthesis of 3-(2-Fluorophenyl)-DL-alanine is mainly divided into two steps. First, a fluorine atom is introduced into the α-hydroxyl group of alanine, usually using a nucleophilic substitution reaction like benzylammonium bromide. Then, the introduced fluorine atom is reduced to hydrogen by a reduction reaction to obtain a target product.
Safety Information:
3-(2-Fluorophenyl)-DL-alanine has low toxicity, but it is still necessary to pay attention to safe use. As with most chemicals, use should follow laboratory procedures. Avoid direct contact with skin and eyes to avoid irritation or injury. Keep away from fire and heat sources during use and storage, and avoid contact with oxidants.
Nature:
3-(2-Fluorophenyl)-DL-alanine is a colorless crystalline solid with a slightly sweet taste at room temperature. It is soluble in water and some organic solvents such as ethanol and dichloromethane. It is a compound with stereoisomers, including both the D-isomer and the L-isomer.
Use:
3-(2-Fluorophenyl)-DL-alanine has certain applications in the pharmaceutical industry. It is an unnatural amino acid that can act as a catalyst in the synthesis of organic compounds as a chiral reagent. In addition, it is also used as an intermediate in the synthesis of biologically active compounds, such as synthetic drugs and pesticides.
Method:
The synthesis of 3-(2-Fluorophenyl)-DL-alanine is mainly divided into two steps. First, a fluorine atom is introduced into the α-hydroxyl group of alanine, usually using a nucleophilic substitution reaction like benzylammonium bromide. Then, the introduced fluorine atom is reduced to hydrogen by a reduction reaction to obtain a target product.
Safety Information:
3-(2-Fluorophenyl)-DL-alanine has low toxicity, but it is still necessary to pay attention to safe use. As with most chemicals, use should follow laboratory procedures. Avoid direct contact with skin and eyes to avoid irritation or injury. Keep away from fire and heat sources during use and storage, and avoid contact with oxidants.
Last Update：2024-04-09 21:01:54
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View History
2-氨基-3-(2-氟苯基)丙酸
5-溴-2-甲基-3-硝基苯甲酸
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6-溴苯并[D]噻唑-2-甲酰胺
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TERT-BUTYL 4-IODOPYRAZOLE-1-CARBOXYLATE
5-溴-2-甲基-3-硝基苯甲酸
titanium(2+), oxo- diethanedioate, diammonium salt, monohydrate
6-溴苯并[D]噻唑-2-甲酰胺
Tail gas (petroleum), catalytic cracked distillate and naphtha stabilizer
3-(4-FLUOROPHENYL)PROPRIONIC ACID
6-氰基-2-氟苯硼酸频哪醇酯
乙烯基封端 聚二甲基硅氧烷
替诺福韦R2-M1Z6杂质
TERT-BUTYL 4-IODOPYRAZOLE-1-CARBOXYLATE