2-氟-4-(3-氟苯基)苯甲腈
3,3'-Difluoro-[1,1'-biphenyl]-4-carbonitrile
CAS: 1214356-07-6
Molecular Formula: C13H7F2N
2-氟-4-(3-氟苯基)苯甲腈 - Names and Identifiers
| Name | 3,3'-Difluoro-[1,1'-biphenyl]-4-carbonitrile |
| Synonyms | 2-Fluoro-4-(3-fluorophenyl)benzonitrile 3,3'-Difluoro-[1,1'-biphenyl]-4-carbonitrile 1,1'-Biphenyl]-4-carbonitrile, 3,3'-difluoro- |
| CAS | 1214356-07-6 |
2-氟-4-(3-氟苯基)苯甲腈 - Physico-chemical Properties
| Molecular Formula | C13H7F2N |
| Molar Mass | 215.2 |
| Storage Condition | 2-8°C |
| Sensitive | IRRITANT |
| MDL | MFCD14699249 |
2-氟-4-(3-氟苯基)苯甲腈 - Introduction
3,3 '-Difluoro-[1,1'-biphenyl]-4-carbonitrile, also known as 3,3 '-difluoro-[1,1'-biphenyl]-4-carbonitrile, chemical formula C14H8F2N. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 3,3 '-Difluoro-[1,1'-biphenyl]-4-carbonitrile is a white crystalline solid.
-Melting point: The melting point range of this compound is 55-59 degrees Celsius.
-Solubility: It has low solubility in commonly used organic solvents, such as ethanol and dimethylformamide.
Use:
3,3 '-Difluoro-[1,1'-biphenyl]-4-carbonitrile has important applications in organic synthesis and medicine:
-Organic synthesis: It can be used as an intermediate for aromatic compounds and used to synthesize other organic compounds.
-Pharmaceutical field: The compound has certain applications in the research and development of new drugs, and may be used as a drug molecular skeleton or potential drug candidate.
Preparation Method:
The preparation method of 3,3 '-Difluoro-[1,1'-biphenyl]-4-carbonitrile can be carried out by the following steps:
-First, 3-fluorophenylboronic acid and 2-bromobenzonitrile are reacted, and heat is released during the synthesis process to produce the compound: 2-bromo-4-(3-fluorophenyl) benzonitrile.
-Then, the obtained 2-bromo-4-(3-fluorophenyl) benzonitrile is reacted with sodium fluoride in acetonitrile solvent to generate 3,3 '-Difluoro-[1,1'-biphenyl]-4-carbonitrile.
Safety Information:
- 3,3 '-Difluoro-[1,1'-biphenyl]-Related Material Safety Specifications (MSDS) for 4-carbonitrile are not available, so specific safety information may be difficult to obtain.
-When handling the compound, appropriate safety measures should be taken, including wearing appropriate personal protective equipment (such as gloves and protective glasses), avoiding contact with skin and inhaling its vapors.
-If you accidentally come into contact with the substance, rinse immediately with plenty of water and seek medical advice.
Nature:
-Appearance: 3,3 '-Difluoro-[1,1'-biphenyl]-4-carbonitrile is a white crystalline solid.
-Melting point: The melting point range of this compound is 55-59 degrees Celsius.
-Solubility: It has low solubility in commonly used organic solvents, such as ethanol and dimethylformamide.
Use:
3,3 '-Difluoro-[1,1'-biphenyl]-4-carbonitrile has important applications in organic synthesis and medicine:
-Organic synthesis: It can be used as an intermediate for aromatic compounds and used to synthesize other organic compounds.
-Pharmaceutical field: The compound has certain applications in the research and development of new drugs, and may be used as a drug molecular skeleton or potential drug candidate.
Preparation Method:
The preparation method of 3,3 '-Difluoro-[1,1'-biphenyl]-4-carbonitrile can be carried out by the following steps:
-First, 3-fluorophenylboronic acid and 2-bromobenzonitrile are reacted, and heat is released during the synthesis process to produce the compound: 2-bromo-4-(3-fluorophenyl) benzonitrile.
-Then, the obtained 2-bromo-4-(3-fluorophenyl) benzonitrile is reacted with sodium fluoride in acetonitrile solvent to generate 3,3 '-Difluoro-[1,1'-biphenyl]-4-carbonitrile.
Safety Information:
- 3,3 '-Difluoro-[1,1'-biphenyl]-Related Material Safety Specifications (MSDS) for 4-carbonitrile are not available, so specific safety information may be difficult to obtain.
-When handling the compound, appropriate safety measures should be taken, including wearing appropriate personal protective equipment (such as gloves and protective glasses), avoiding contact with skin and inhaling its vapors.
-If you accidentally come into contact with the substance, rinse immediately with plenty of water and seek medical advice.
Last Update：2024-04-09 20:49:11
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