2-丁基-3-(4-甲氧基苯甲酰基)-5-硝基苯并呋喃(决奈达隆中间体)

2-丁基-3-(4-甲氧基苯甲酰基)-5-硝基苯并呋喃(决奈达隆中间体) - Names and Identifiers

Name	2-butyl-3-(4-methoxybenzoyl)-5-nitrobenzofuran
Synonyms	Dron-4 Dronedarone Impurity E 2-butyl-3-(4-methoxybenzoyl)-5-nitrobenzofuran 2-N-Butyl-3-(4-Methoxybenzoyl)-5-Nitrobenzofuran 2-butyl-3-[(4-Methoxyphenyl)carbonyl]-5-nitro-1-benzofuran (2-butyl-5-nitro-3-benzofuranyl)(4-methoxyphenyl)Methanone (2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone 2-Butyl-3-[(4-methoxyphenyl)carbonyl]-5-nitro-1-benzofuran (2-Butyl-5-nitro-1-benzofuran-3-yl)(4-methoxyphenyl)methanone Methanone, (2-butyl-5-nitro-3-benzofuranyl)(4-methoxyphenyl)- (2-butyl-5-nitro-1-benzofuran-3-yl)-(4-methoxyphenyl)methanone (2-Butyl-5-nitro-benzofuran-3-yl)-(4-methoxy-phenyl)-methanone
CAS	141627-42-1
EINECS	604-241-8
InChI	InChI=1/C20H19NO5/c1-3-4-5-18-19(20(22)13-6-9-15(25-2)10-7-13)16-12-14(21(23)24)8-11-17(16)26-18/h6-12H,3-5H2,1-2H3

2-丁基-3-(4-甲氧基苯甲酰基)-5-硝基苯并呋喃(决奈达隆中间体) - Physico-chemical Properties

Molecular Formula	C20H19NO5
Molar Mass	353.37
Density	1.234±0.06 g/cm3(Predicted)
Boling Point	537.7±50.0 °C(Predicted)
Flash Point	279.007°C
Vapor Presure	0mmHg at 25°C
Storage Condition	-20℃
Refractive Index	1.603
Use	This product is for scientific research only and shall not be used for other purposes.

2-丁基-3-(4-甲氧基苯甲酰基)-5-硝基苯并呋喃(决奈达隆中间体) - Introduction

2-butyl -3-(4-methoxybenzoyl)-5-nitrobenzofuran, chemical formula C17H17NO5, molecular weight 311.32. The following is a description of its nature, use, preparation and safety information:

Properties: 2-Butyl -3-(4-methoxybenzoyl)-5-nitrobenzofuran is a white to pale yellow crystalline solid. It has a melting point of about 92-96°C and a boiling point of 390°C. It can form yellow to orange-red solutions in solvents. The compound may be stable in air, but may lose certain properties in light.

Purpose: 2-butyl -3-(4-methoxybenzoyl)-5-nitrobenzofuran is a commonly used drug intermediates, widely used in the field of medicine. It can be used as a synthetic raw material for anticancer drugs, anti-inflammatory drugs and antiviral drugs.

Preparation Method: The synthesis of 2-butyl -3-(4-methoxybenzoyl)-5-nitrobenzofuran is usually accomplished by a multi-step reaction. Common preparation methods include: first reacting ethyl p-methoxybenzoate with bromobutane to produce ethyl 2-butyl-3-methoxybenzoate; then reacting the ester compound with a nitrating reagent to produce 2-butyl -3-(4-methoxybenzoyl)-5-nitrobenzofuran.

Last Update：2024-04-09 18:58:34