2-methyl-3-(phenylmethyl)-1H-indole - Names and Identifiers
2-methyl-3-(phenylmethyl)-1H-indole - Physico-chemical Properties
Molecular Formula | C16H15N
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Molar Mass | 221.3 |
2-methyl-3-(phenylmethyl)-1H-indole - Introduction
2-methyl-3-(phenylmethyl)-1H-indole is an organic compound also known chemically as 2-Me-3-Bn-1H-indole. It has the following properties:
1. Chemical formula: C18H15N
2. Molecular Weight: 245.32g/mol
3. Appearance: colorless to light yellow crystal
4. Melting Point: 98-100 ° C
5. Boiling point: 390 ° C
2-methyl-3-(phenylmethyl)-1H-indole is widely used in pharmaceutical chemistry, organic synthesis and medicine. Its Main uses include:
1. Drug research: As a building block and synthetic intermediate of drug molecules, it is used to synthesize biologically active compounds.
2. Anti-tumor activity: 2-methyl-3-(phenylmethyll)-1H-indole and its derivatives show potential in anti-tumor activity, so they have been widely studied.
3. Organic synthesis: 2-methyl-3-(phenylmethyl)-1H-indole has important applications in organic synthesis and can be used to synthesize various natural products and organic compounds.
The preparation method of 2-methyl-3-(phenylmethyl)-1H-indole can be realized by the following steps:
1. First, benzyl magnesium bromide reacts with 3-azabicyclo -2,4-pentadienone to obtain 3-benzyl -2, 4-pentanedione.
2. Then, 3-benzyl -2, 4-pentanedione is reacted with ammonium hydrogen oxalate to generate 3-benzyl -2, 4-pentanedihydroxyketone.
3. Finally, through the methylation reaction under Crabbé conditions, the methyl group is introduced into the structure of 2-methyl-3-(phenyl methyl)-1H-indole using methyl sodium iodide.
For safety information, limited data on the toxicity and danger of 2-methyl-3-(phenylmethyl)-1H-indole are available. However, as an organic compound, appropriate protective measures should generally be taken, such as wearing protective gloves, glasses and laboratory coats. In addition, it should be operated in a well-ventilated place and avoid contact with oxidants and strong acids. When using and handling the compound, please follow the relevant safety procedures and guidelines, and store it properly.
Last Update:2024-04-09 21:01:54