2-hydroxy-4-(tridluoromethyl)pyridine
2-hydroxy-4-(trifluoromethyl)pyridine
CAS: 50650-59-4
Molecular Formula: C6H4F3NO
2-hydroxy-4-(tridluoromethyl)pyridine - Names and Identifiers
2-hydroxy-4-(tridluoromethyl)pyridine - Physico-chemical Properties
| Molecular Formula | C6H4F3NO |
| Molar Mass | 163.1 |
| Density | 1.398±0.06 g/cm3(Predicted) |
| Melting Point | 161-165 °C (lit.) |
| Boling Point | 221.2±40.0 °C(Predicted) |
| Flash Point | 87.6°C |
| Solubility | Soluble in methanol. |
| Vapor Presure | 0.108mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Light yellow to Light orange |
| pKa | 10.76±0.10(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.436 |
2-hydroxy-4-(tridluoromethyl)pyridine - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S39 - Wear eye / face protection. |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Class | IRRITANT |
2-hydroxy-4-(tridluoromethyl)pyridine - Introduction
2-hydroxy-4-(trifluoromethyl)pyridine is an organic compound with the chemical formula C6H4F3NO. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: colorless liquid or crystalline solid;
-hydrochloride form: white crystal;
-Solubility: Soluble in most organic solvents, such as ethanol, ether;
-Melting point: about 56-60°C;
-Boiling point: about 112-114°C;
-Density: about 1.37 g/cm ^ 3;
-Flash point: about 99°C.
Use:
- 2-hydroxy-4-(trifluoromethyl)pyridine is commonly used in drug synthesis, pesticide synthesis and preparation of functional materials;
-It can also be used as a catalyst in organic synthesis;
-Due to its stability and unique structure, it has a wide range of application prospects in the fields of medicine and agriculture.
Preparation Method:
Common preparation methods include the following:
-reaction using pyridine and trifluoromethylphthalic anhydride to obtain 2-hydroxy-4-(trifluoromethyl)pyridine;
-Reaction of trifluoromethyl hydrofluoride using pyridine to give 2-hydroxy-4-(trifluoromethyl)pyridine.
Safety Information:
-During use, care should be taken to avoid contact with skin and eyes;
-in the operation, should use appropriate protective gloves and glasses;
-avoid inhaling its vapor or dust;
-In case of contact, immediately flush the affected area with plenty of water and seek medical assistance.
Nature:
-Appearance: colorless liquid or crystalline solid;
-hydrochloride form: white crystal;
-Solubility: Soluble in most organic solvents, such as ethanol, ether;
-Melting point: about 56-60°C;
-Boiling point: about 112-114°C;
-Density: about 1.37 g/cm ^ 3;
-Flash point: about 99°C.
Use:
- 2-hydroxy-4-(trifluoromethyl)pyridine is commonly used in drug synthesis, pesticide synthesis and preparation of functional materials;
-It can also be used as a catalyst in organic synthesis;
-Due to its stability and unique structure, it has a wide range of application prospects in the fields of medicine and agriculture.
Preparation Method:
Common preparation methods include the following:
-reaction using pyridine and trifluoromethylphthalic anhydride to obtain 2-hydroxy-4-(trifluoromethyl)pyridine;
-Reaction of trifluoromethyl hydrofluoride using pyridine to give 2-hydroxy-4-(trifluoromethyl)pyridine.
Safety Information:
-During use, care should be taken to avoid contact with skin and eyes;
-in the operation, should use appropriate protective gloves and glasses;
-avoid inhaling its vapor or dust;
-In case of contact, immediately flush the affected area with plenty of water and seek medical assistance.
Last Update：2024-04-09 15:17:58
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View History
2-hydroxy-4-(tridluoromethyl)pyridine
2-(2-HYDROXY-1-NAPHTHYL)ACETIC ACID
Mecillinam VETRANAL
Terephthalaldehydic acid
NANDROLONE LAURATE
2-Amino-6-hydroxy-5-methyl-4-hexenoic acid
2-hydroxypropyl (9E)-octadec-9-enoate
methyl 1-[(2,4-difluorophenoxy)methyl]-1H-pyrazole-3-carboxylate
3-(2-氨乙基)-1-叔丁基羰基哌啶
Red AR
2-(2-HYDROXY-1-NAPHTHYL)ACETIC ACID
Mecillinam VETRANAL
Terephthalaldehydic acid
NANDROLONE LAURATE
2-Amino-6-hydroxy-5-methyl-4-hexenoic acid
2-hydroxypropyl (9E)-octadec-9-enoate
methyl 1-[(2,4-difluorophenoxy)methyl]-1H-pyrazole-3-carboxylate
3-(2-氨乙基)-1-叔丁基羰基哌啶
Red AR