2-CHLORO-4,5-DIFLUOROPHENYLACETONE

2-CHLORO-4,5-DIFLUOROPHENYLACETONE - Names and Identifiers

Name	2'-Chloro-4',5'-difluoroacetophenone
Synonyms	2-Chloro-4,5-difluroacetophenone 2-CHLORO-4,5-DIFLUOROACETOPHENONE 2-CHLORO-4,5-DIFLUOROPHENYLACETONE 2'-CHLORO-4',5'-DIFLUOROACETOPHENONE 2'-Chloro-4',5'-difluoroacetophenone 2-CHLORO-4,5-DIFLUOROPHENYLACETOPHENONE 1-(2-chloro-4,5-difluorophenyl)ethanone 2'-chloro-4',5'-difluoroacetophenonedup 21889
CAS	121872-94-4

2-CHLORO-4,5-DIFLUOROPHENYLACETONE - Physico-chemical Properties

Molecular Formula	C8H5ClF2O
Molar Mass	190.57
Density	1.348±0.06 g/cm3(Predicted)
Boling Point	211.4±35.0 °C(Predicted)

2-CHLORO-4,5-DIFLUOROPHENYLACETONE - Risk and Safety

Hazard Symbols	Xi - Irritant
Hazard Class	IRRITANT

2-CHLORO-4,5-DIFLUOROPHENYLACETONE - References

Application

2 '-chloro-4',5 '-difluoroacetophenone is an organic intermediate, it can be obtained from the acylation of 1-chloro-3, 4-difluorobenzene with acetyl chloride. 2 '-chloro-4',5 '-difluoroacetophenone can be used for the oxidation of 2-chloro-4, 5-difluorobenzoic acid (CDFBA). 2-chloro-4, 5-difluorobenzoic acid is an important intermediate of medicine and pesticide. It is mainly used in the production of novel antibacterial drugs, fluoropyranoic acids and cardiovascular and cerebrovascular drugs.

preparation

at a temperature of 20 ° to 40°C, 23.6g(0.3mol) acetyl chloride is added to a mixture comprising 29.7g(0.2mol) of 1-chloro-3, 4-difluorobenzene and 40.0g(0.3mol) of aluminium chloride, the mixture was then stirred at 120 °c for 2 hours. While still hot, the mixture was poured onto 250g of ice and the separated oil was extracted with ethyl chloride. The extract was neutralized and washed with water, and the solvent was distilled off under reduced pressure to obtain 31.2g (yield: 82%) of 2 '-chloro-4',5 '-difluoroacetophenone, Boiling Point: 65 °c -67 °c/4-5mmHg.

Last Update：2024-04-09 02:00:16

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