2-Bromo-4'-nitroacetophenone
α-Bromo-4-nitroacetophenone
CAS: 99-81-0
Molecular Formula: C8H6BrNO3
2-Bromo-4'-nitroacetophenone - Names and Identifiers
| Name | α-Bromo-4-nitroacetophenone |
| Synonyms | ASISCHEM D48949 AKOS BBS-00003952 4-NITROPHENACYL BROMIDE 4'-NITROPHENACYL BROMIDE α-Bromo-4-nitroacetophenone A-BROMO-P-NITROACETOPHENONE 2-Bromo-4-nitroacentophenone 2-bromo-4'-nitroacetophenone 2-BROMO-4'-NITROACENTOPHENONE ALPHA-BROMO-P-NITROACETOPHENONE ALPHA-BROMO-4-NITROACETOPHENONE 2-bromo-1-(4-nitrophenyl)ethanone |
| CAS | 99-81-0 |
| EINECS | 202-789-9 |
| InChI | InChI=1/C8H6BrNO3/c9-5-8(11)6-1-3-7(4-2-6)10(12)13/h1-4H,5H2 |
2-Bromo-4'-nitroacetophenone - Physico-chemical Properties
| Molecular Formula | C8H6BrNO3 |
| Molar Mass | 244.04 |
| Density | 1.8033 (rough estimate) |
| Melting Point | 94-99°C(lit.) |
| Boling Point | 325.2±17.0 °C(Predicted) |
| Flash Point | 150.5°C |
| Vapor Presure | 0.000233mmHg at 25°C |
| Appearance | Crystalline Powder |
| Color | Yellow to orange |
| BRN | 393567 |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.6090 (estimate) |
| Use | Used as raw materials for organic synthesis and pharmaceutical intermediates |
2-Bromo-4'-nitroacetophenone - Risk and Safety
| Risk Codes | R34 - Causes burns R37 - Irritating to the respiratory system |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3261 8/PG 2 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 19 |
| TSCA | Yes |
| HS Code | 29147000 |
| Hazard Note | Irritant |
| Hazard Class | 8 |
| Packing Group | III |
2-Bromo-4'-nitroacetophenone - Nature
Open Data Verified Data
crystalline solid, melting point 98 °c.
Last Update：2024-01-02 23:10:35
2-Bromo-4'-nitroacetophenone - Preparation Method
Open Data Verified Data
It is prepared by bromination of p-nitroacetophenone. The solvent chlorobenzene and p-nitroacetophenone are added into the reaction vessel, and a small amount of bromine is added dropwise at 18 ℃, the temperature is controlled at 26~28 ℃, and bromine is added dropwise. After dropping, the reaction is carried out for 1 hour, and the temperature is raised to drive out HBr, and the post-treatment is obtained.
Last Update：2022-01-01 10:50:44
2-Bromo-4'-nitroacetophenone - Use
Open Data Verified Data
A pharmaceutical intermediate for the synthesis of chloramphenicol and the like.
Last Update：2022-01-01 10:50:43
2-Bromo-4'-nitroacetophenone - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | used as raw materials for organic synthesis and pharmaceutical intermediates, etc. |
| production method | p-nitroacetophenone bromination, reaction formula: the solvent chlorobenzene and p-nitroacetophenone into the reaction kettle, A small amount of bromine was added dropwise at 18 ℃, and the reaction was started when hydrogen bromide was released. The temperature was controlled at 26~28 ℃, this product was obtained by post-treatment. |
Last Update：2024-04-09 15:16:52
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View History
2-Bromo-4'-nitroacetophenone
Einecs 281-073-8
2-[4-(propan-2-yl)phenyl]piperidine hydrochloride
1H-Pyrazole-1-carbothioamide,4-[2-(2,5-dichlorophenyl)hydrazinylidene]-4,5-dihydro-3-methyl-5-oxo-
Cyclohexanecarboxylic acid, 1-(1-isoquinolinyl)-
Sodium phenyl phosphate dihydrate dibasic
ANTI-SARCOMERIC ACTIN
fmoc-alpha-methylalanine
磺达肝癸钠单糖中间体
2-(2-乙氧基)乙酸乙酯
Einecs 281-073-8
2-[4-(propan-2-yl)phenyl]piperidine hydrochloride
1H-Pyrazole-1-carbothioamide,4-[2-(2,5-dichlorophenyl)hydrazinylidene]-4,5-dihydro-3-methyl-5-oxo-
Cyclohexanecarboxylic acid, 1-(1-isoquinolinyl)-
Sodium phenyl phosphate dihydrate dibasic
ANTI-SARCOMERIC ACTIN
fmoc-alpha-methylalanine
磺达肝癸钠单糖中间体
2-(2-乙氧基)乙酸乙酯