2-(氨基甲基)咪唑二盐酸盐

2-(氨基甲基)咪唑二盐酸盐 - Names and Identifiers

Name	2-Aminomethyl-1H-imidazole dihydrochloride
Synonyms	2-Aminomethyl-1H-imidazole 2-Aminomethyl-1H-imidazolex2HCl C-(1H-IMIDAZOL-2-YL)-METHYLAMINE 2HCL 2-AMINOMETHYL-1H-IMIDAZOLE DIHYDROCHLORIDE 2-Aminomethyl-1H-imidazole dihydrochloride 1H-IMIDAZOL-2-YLMETHYLAMINE DIHYDROCHLORIDE 1H-IMIDAZOL-2-YLMETHANAMINE DIHYDROCHLORIDE C-(1H-IMIDAZOL-2-YL)-METHYLAMINE DIHYDROCHLORIDE
CAS	22600-77-7

2-(氨基甲基)咪唑二盐酸盐 - Physico-chemical Properties

Molecular Formula	C4H9Cl2N3
Molar Mass	170.04
Melting Point	240-242℃
Boling Point	359℃ at 760 mmHg
Storage Condition	Inert atmosphere,Room Temperature

2-(氨基甲基)咪唑二盐酸盐 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3
Hazard Class	IRRITANT

2-(氨基甲基)咪唑二盐酸盐 - Reference Information

application

2-ethylamine methylimidazole dihydrochloride is an organic synthesis intermediate and pharmaceutical intermediate, which can be used in laboratory research and development process and chemical production process.

Preparation

2-ethylaminomethylimidazole dihydrochloride was prepared as follows: 1) 1H-imidazol-2-formaldehyde The pH of the aqueous solution containing 1H-imidazol-2-formaldehyde hydrochloride was adjusted to 9.5 or 6.5 with NaOH. Then, a continuous extraction device was used to extract with dichloromethane. Finally, the organic layer was dried by anhydrous Na2SO4 and evaporated to dryness under reduced pressure. Solid 1H-imidazol-2-formaldehyde was crystallized from methanol/water (4.42g,92% g or 4.29g,89% at pH = 9.5 or 6.5, respectively) with yields (4.42g,92% g or 4.29g,89% at pH = 9.5 or 6.5, respectively). Melting point: 206-207 ℃. 2) 1H-imidazol-2-formaldehyde formaldehyde oxime dissolves imidazol-2-formaldehyde (2.0g,20.8mmol) in anhydrous ethanol (320mL), and then adds sodium carbonate (1.0g) and hydroxylamine hydrochloride (1.5g,21.6mmol) to the solution. The mixture was refluxed for 2h and the solvent was evaporated under reduced pressure. The crude product was purified by TLC silica chromatography using CH2Cl2/methanol (90 ∶ 10v/v) as eluent to give 1H-imidazol-2-formaldehyde oxime (1.43g,62%) in yellow solid form. Melting point: 171-172 ℃. 3) 2-ethylaminomethylimidazole dihydrochloride Sodium borohydride (200mg,5.3mmol) was added to a solution of 1 H-imidazol-2-formaldehyde formaldehyde oxime (1.0g,10.4mmol) of anhydrous ethanol (100mL). The mixture was stirred at 20°C for 2h, then poured on water (50mL), and the mixture was extracted with ethyl acetate (3 × 50mL). The combined organic layers were dried by anhydrous Na2SO4 and evaporated under reduced pressure to dryness. The crude product was crystallized from methanol/water to obtain 2-ethylamine methylimidazole dihydrochloride, which was a yellow solid (0.77g,75%).

Last Update：2024-04-10 22:29:15