2-(difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid
benactyzine hydrochloride
CAS: 57-37-4
Molecular Formula: C20H26ClNO3
2-(difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid - Names and Identifiers
| Name | benactyzine hydrochloride |
| Synonyms | Amizyl Benactyzine HCL BENACTYCIN HYDROCHLORIDE benactyzine hydrochloride 2-(diethylamino)-ethanobenzilatehydrochloride 2-Diethylaminoethyl Diphenylglycolate Hydrochloride 2-(difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid 2-(Difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid [czech] 2-(Diethylamino)ethyl benzilate hydrochloride, Benactyzine, α-Hydroxy-α-phenylbenzeneacetic acid 2-(diethylamino)ethyl ester |
| CAS | 57-37-4 |
| EINECS | 200-324-4 |
| InChI | InChI=1/C20H25NO3.ClH/c1-3-21(4-2)15-16-24-19(22)20(23,17-11-7-5-8-12-17)18-13-9-6-10-14-18;/h5-14,23H,3-4,15-16H2,1-2H3;1H |
2-(difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid - Physico-chemical Properties
| Molecular Formula | C20H26ClNO3 |
| Molar Mass | 363.88 |
| Melting Point | 177-179°C(lit.) |
| Boling Point | 409.3°C at 760 mmHg |
| Flash Point | 201.4°C |
| Solubility | DMSO (Slightly, Heated), Methanol (Slightly) |
| Vapor Presure | 1.96E-07mmHg at 25°C |
| Appearance | Solid |
| Color | Crystals from Me2CO |
| Merck | 14,1029 |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Physical and Chemical Properties | White or almost white crystalline powder. Melting point 177-181 °c. 14.9g of the product can be dissolved in of water at 25 C, and it is almost insoluble in ether. No odor, slightly bitter taste. The base ([302-40-9]) had a melting point of 51 °c. |
| In vitro study | Benactyzine hydrochloride and drofenine are widely used anticholinergic drugs which are also competitive inhibitors of BChE with K i values of 0.010±0.001 and 0.003±0.000 mM, respectively. Results indicate that the inhibition of BChE by Benactyzine hydrochloride is pure or partial competitive. Pure competitive inhibition can be distinguished from partial competitive inhibition by plotting v vs [Benactyzine] at a fixed [BTCh]. |
| In vivo study | Benactyzine hydrochloride (1 mg/kg) does not influence the attention response. Benactyzine hydrochloride increases the duration of the exploratory-motor reaction, but slightly diminishes the salivation elicited by acetylcholine. There is no blocking effect of Benactyzine hydrochloride and promazine on the EEG-seizure activity elicited by acetylcholine, and almost no inhibitory effect on emotional reactions. Emotional reactions are blocked by high doses of imipramine and promazine, but not by Benactyzine hydrochloride. The data indicates that imipramine, promazine and Benactyzine hydrochloride influence the autonomic effects of serotonin in different ways. Promazine, and especially Benactyzine hydrochloride, inhibit and shorten the period of salivation elicited by the intra-amygdaloid injection of serotonin. |
2-(difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. |
| Safety Description | S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | DD2800000 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 orl-rat: 184 mg/kg TXAPA9 1,42,59 |
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Product Name: Benactyzine hydrochloride Visit Supplier Webpage Request for quotationCAS: 57-37-4
Tel: +86-400-900-4166
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Mobile: +86-18621343501
QQ: 2881950922
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View History
2-(difenyl-hydroxyacetoxy)ethyl-diethylammoniumchlorid
5-TRIFLUOROMETHYLINICOTINIC ACID
2-(9-Oxoxanthen-2-yl)propionic Acid 1,5-Diazabicyclo[4.3.0]non-5-ene Salt
2-([(DIMETHYLAMINO)METHYLENE]AMINO)-5-(4-METHOXYBENZOYL)-3-[2-(4-METHOXYPHENYL)-2-OXOETHYL]-1,3-THIAZOL-3-IUM BROMIDE
5-TRIFLUOROMETHYLINICOTINIC ACID
2-(9-Oxoxanthen-2-yl)propionic Acid 1,5-Diazabicyclo[4.3.0]non-5-ene Salt
2-([(DIMETHYLAMINO)METHYLENE]AMINO)-5-(4-METHOXYBENZOYL)-3-[2-(4-METHOXYPHENYL)-2-OXOETHYL]-1,3-THIAZOL-3-IUM BROMIDE