2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane - Names and Identifiers

Name	2-(4-bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Synonyms	4-Bromophenylboronic acid pinacol ester 4-Bromophenylboronic acid,pinacol ester 2-(4-bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 1,3,2-Dioxaborolane, 2-(4-bromophenyl)-4,4,5,5-tetramethyl- 2-(4-BROMO-PHENYL)-4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLANE 2-(4-Bromo-Phenyl)-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane 1-Bromo-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene
CAS	68716-49-4
InChI	InChI=1/C12H16BBrO2/c1-11(2)12(3,4)16-13(15-11)9-5-7-10(14)8-6-9/h5-8H,1-4H3

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane - Physico-chemical Properties

Molecular Formula	C12H16BBrO2
Molar Mass	282.97
Density	1.29±0.1 g/cm3(Predicted)
Melting Point	69.0 to 73.0 °C
Boling Point	324.1±25.0 °C(Predicted)
Flash Point	149.839°C
Vapor Presure	0mmHg at 25°C
Appearance	powder to crystal
Color	White to Almost white
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.528

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane - Introduction

2-(4-bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is an organic compound with the chemical formula C13H17BBrO2. The following is a detailed description of its nature, use, preparation and safety information:

Nature:
-Appearance: Colorless to light yellow liquid
-Molecular weight: 285.99g/mol
-Melting point: The melting point of the compound ranges from -20 ℃ to -17 ℃
-Boiling point: The boiling point of the compound ranges from 195 ℃ to 197 ℃
-Density: The density of the compound is 1.28g/cm³
-Solubility: Soluble in organic solvents such as ethanol, dimethylformamide and dimethyl sulfoxide, insoluble in water

Use:
- 2-(4-bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is a common boron reagent in organic synthesis, which is widely used in the synthesis of phenyl, bromophenyl and other functional groups.
-It can be used to catalyze coupling reactions, C- C bond connection reactions and C- X bond formation reactions, such as Suzuki-Miyaura coupling reactions.

Preparation Method:
- 2-(4-bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is mainly prepared by the reaction of benzeneboronate and 4-bromobenzene. The specific reaction steps are as follows:
1. the benzeneborate and 4-bromobenzene dissolved in a suitable organic solvent, commonly used organic solvents such as ethanol, dimethylformamide.
2. The two substances are reacted at an appropriate temperature, and the reaction time is usually a few hours to a few days.
3. After the reaction is completed, the desired product is extracted by an appropriate method such as distillation or crystallization.

Safety Information:
- 2-(4-bromophene)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is an organic compound with potential danger.
-Avoid contact with skin, eyes and respiratory tract during handling and storage. It is recommended to wear appropriate protective equipment, such as protective gloves and glasses.
-Avoid contact with strong oxidants and strong acids to avoid dangerous reactions.
-Before use, please carefully read and follow the relevant safety instructions and material safety data sheets (MSDS).

Please note that this is only a brief introduction, and the specific nature, use, formulation and safety information should refer to authoritative literature and related information. When handling and using this compound, strictly follow safe practices and procedures.

Last Update：2024-04-10 22:29:15