2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-D-glucopyranoside
Rutin
CAS: 153-18-4
Molecular Formula: C27H30O16
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-D-glucopyranoside - Names and Identifiers
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-D-glucopyranoside - Physico-chemical Properties
| Molecular Formula | C27H30O16 |
| Molar Mass | 610.52 |
| Density | 1.3881 (rough estimate) |
| Melting Point | 195°C (dec.)(lit.) |
| Boling Point | 576.13°C (rough estimate) |
| Specific Rotation(α) | D23 +13.82° (ethanol); D23 -39.43° (pyridine) |
| Water Solubility | 12.5 g/100 mL |
| Solubility | DMSO : 40 mg/mL requires ultrasound. Mother liquor preservation: sub-package and freeze storage to avoid repeated freezing and thawing;-20 ℃,1 month;-80 ℃,6 months (after dilution, the solution temperature is low and storage may precipitate, try to use it now) Cell experiment: Dissolve with DMSO first: then culture |
| Appearance | Light yellow needle crystal |
| Color | yellow to green |
| Merck | 8304 |
| pKa | 6.17±0.40(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Stability | Hygroscopic |
| Sensitive | Sensitive to light |
| Refractive Index | 1.7650 (estimate) |
| MDL | MFCD00006830 |
| Physical and Chemical Properties | Light yellow needle-like crystals, Melting Point: 176-178 degrees Celsius. 1G dissolved in 7ml methanol, 8000ml water, 200ml boiling water. |
| Use | Has anti-inflammatory effect; Vitamin P-like effect, with the maintenance of vascular resistance, reduce its permeability, reduce fragility and other effects, fat-removing effect on fatty infiltration of the liver, combined with glutathione lipid removal effect is more obvious; Antiviral effect and inhibition of aldose reductase. |
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-D-glucopyranoside - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | VM2975000 |
| FLUKA BRAND F CODES | 8 |
| HS Code | 29381000 |
| Toxicity | LD50 i.v. in mice: 950 mg/kg (propylene glycol soln) (Harrison) |
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-D-glucopyranoside - Introduction
Open Data Unverified Data
Rutin (pinyin: l_d and ng, English: Rutin, chemical name: C.I. 75730), also known as Rutin, Vitamin p, purple mistletoe glycosides, Rutin, Rutin powder, Rutong, luotong, picroside. Mainly used for anti-inflammatory, antiviral, etc., in clinical for the prevention and treatment of cerebral hemorrhage, hypertension, retinal hemorrhage, purulent and acute hemorrhagic nephritis. Ruta graveolens L. Whole grass volatile oil, legume Sophora Scphora japonica L. The main component of the fruit (sophorae fructus), Hypericum aseyron L. Photocatechu Berchemia polyphylla Wall, var leioclada Hand. - Mazz . , euphorbiaceae wild Platanus Mallotus Japan Muell . -Arg, leaf, Polygonaceae plant buckwheat Fagopyrum esculentum Moench seedlings.
Last Update：2022-01-01 08:48:51
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-D-glucopyranoside - Plant Origin
Open Data Unverified Data
Product Source: rutin leaf, tobacco leaf, jujube, apricot, orange peel, tomato, buckwheat flower, etc
- Ruta graveolens L. Volatile oil from whole grass
- The main components of the fruit of Sophora japonica L. (sophorae fructus)
- hypericin aseyron L. Whole grass
- rhamnocco plant photocatechu Berchemia polyphylla Wall, var leioclada Hand. - Mazz .
- Euphorbiaceae wild Platanus Mallotus Japan Muell . - Arg leaf
- buckwheat Fagopyrum esculum Moench seedlings
Last Update：2022-01-01 08:48:51
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-D-glucopyranoside - Nature
Open Data Verified Data
is a pale yellow or light green needle-like crystal or crystalline powder. Usually there are three water of crystallization, in the case of 95~97 deg C drying lost two water of crystallization, drying at 110 deg C/1. 33kPa under the condition of 12h can become anhydrous. The anhydrous became Brown at 125 °c, flexible and plastic at 195-197 °c, and decomposed at 214-215 °c. The specific optical rotation was 13. 82 °c (ethanol as solvent). Rutin structure in the presence of four phenolic hydroxyl groups, so its aqueous solution encountered Fe3 blue green. Anhydrous material is easy to absorb moisture, almost insoluble in water, chloroform, ether, benzene, carbon disulfide and petroleum ether, soluble in pyridine, DMF and alkaline aqueous solution, slightly soluble in ethanol, acetone and ethyl acetate. With the function of vitamin P, can prevent capillary fragility caused by hemorrhagic disease.
Last Update：2024-01-02 23:10:35
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-D-glucopyranoside - Preparation Method
Open Data Verified Data
rutin is a kind of flavonol glycoside compound with wide source, which exists in plants, especially in Sophora japonica and Sophora japonica. Generally tartary buckwheat leaves, flower buds of Sophora japonica (Sophora japonica), red beans and other raw materials. The extraction methods include ethanol extraction, hot water extraction, hot alkali solution extraction, cold alkali solution extraction and sodium sulfite hot alkali solution extraction.
Last Update：2022-01-01 11:13:47
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-D-glucopyranoside - Plant extract
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- rutin is a flavonol compounds quercetin rutin, is a kind of flavonoids extracted from plants, the presence of rutin, tartary buckwheat, Sophora Bud, catalpa bungei leaves, tomato stem, in leaves, seed hulls and the like, about 3% is contained in the dried buckwheat to be flowering, and rutin is contained in Jujube, Hawthorn, ginkgo, medlar, motherwort, bupleurum, Prunella vulgaris, aloe, Gynostemma pentaphyllum and the like. In the legume plant Sophora japonica L. (Sophora japonica L.) flower bud of Sophora japonica, content can reach more than 20%, is the main raw material for the extraction of rutin in China's pharmaceutical industry. Rutin can be decomposed by adding water when exposed to strong acidity and alkalinity. In alkaline food color instability, antioxidant capacity. In ethanol can improve the light resistance of the pigment preparation, prevent the gradual disappearance or change of the flavor, and the combination with vitamin E can improve its antioxidant capacity.
- the inhibitory effect of rutin on lipid peroxidation is related to its enhancement of SOD activity and scavenging of oxygen free radicals. Xiavei Wood found that rutin has a strong scavenging effect on O2-, and the scavenging efficiency can reach more than 96%. Rutin, as a chelating agent of Fe2 +, can inhibit Fenton reaction and chain reaction of lipid peroxidation and has obvious anti-lipid peroxidation effect.
- Foreign countries have developed a variety of rutin health food. Sophora japonica has a strong antioxidant effect on edible oil. The free radical scavenging rate of Sophora japonica L. Extract can reach 40% ~ 70%, which can be used as a new edible oil and fat food additive with health care function, and can also be used for cold drinks, beverages, cakes, processed meat products and processed aquatic products. Tartary buckwheat rutin health factor has the effect of lowering blood fat, lowering blood pressure, lowering urine sugar and weight loss, and has been developed into a delicious and convenient snack (tartary buckwheat tea, tartary buckwheat rice, tartary buckwheat noodles, etc.). The rutin was hydrolyzed with 2% dilute H2SO4 for 1H, and the precipitate was filtered after cooling, washed with water and dried, and the crude product was recrystallized with ethanol to obtain high quality quercetin. When other flavonoids such as quercetin are mixed with α-tocopherol or catechin, an additive effect can be exhibited.
Last Update：2022-01-01 08:48:52
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-D-glucopyranoside - Use
Open Data Verified Data
It can be used as an edible antioxidant and a nutrition enhancer. With the maintenance of vascular resistance, reduce its permeability, reduce the role of brittleness. Can be used for the prevention and treatment of cerebral hemorrhage, hypertension, retinal hemorrhage, purpura and acute hemorrhagic nephritis and other diseases.
Last Update：2022-01-01 11:13:47
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-D-glucopyranoside - Sophora japonica
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Sophora japonica L. Is the flower bud of Sophora japonica L., which is like a rice grain when the flower is not opened. It is very fresh and stained with fried water. Sophora japonica has the function of cooling blood to stop bleeding, clearing liver and purging fire. For blood in the stool, hemorrhoidal blood, blood dysentery, bleeding, hematemesis, blood, liver and red eyes, Head Pain vertigo. Most of the processing is raw, saute or fried charcoal.
collection
when the summer flower is not open, the flower bud is harvested, the impurity is removed, and the sun is exposed. Medicinal herbs are mainly produced in Hebei, Shandong, Henan, Jiangsu, Guangdong, Guangxi, Liaoning, most parts of the country.
trait
The flower bud is ovoid or oblong, 2.5~1.5 in length and ~ in width; It is yellowish brown or yellow-green in appearance, slightly retracted, with a bell-shaped Calyx in the lower part, apex with less pronounced 5-dentate fissures, sometimes short-stalked, upper one with an unopened crown, varying in size, with sparse white pubescence outside the calyx and the Crown. Friable. The taste was slightly bitter. The flower bud foot strong, Calyx color green and thick, no branch stem is better.
component
Sophora japonica and Sophora japonica contain basically the same components, mainly containing triterpenoid saponins, red bean saponins, soybean saponins, Sophora japonica saponins. It also contains flavonoids, quercetin, rutin, isorhamnetin, isorhamnet-3-target glucosides, kaempferol -3-rutin. It also contains betulin and Sophora japonica diol. Flower oil contains lauric acid, dodecenoic acid, myristic acid and other fatty acids and β-sitosterol. It also contains tannin.
Last Update：2022-01-01 08:48:53
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-D-glucopyranoside - Rutin derivatives
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troxerutin, also known as venoruton, is one of the most important rutin derivatives. It is a semi-synthetic water-soluble flavonoid compound made by hydroxyethylation of rutin, which has good curative effect on occlusive vascular disease, is a better treatment of occlusive cerebrovascular disease drugs. It can inhibit platelet aggregation, prevent thrombosis, increase blood oxygen content, improve microcirculation, promote angiogenesis, increase the role of collateral circulation. At the same time, it has a protective effect on endothelial cells, can resist the vascular injury caused by serotonin and bradykinin, increase the Capillary resistance, reduce the capillary permeability, and prevent the edema caused by the increase of vascular permeability. Pharmacological experiments show that this product has a significant protective effect on acute ischemic brain injury. Clinical troxerutin can be used for the treatment of cerebral thrombosis and cerebral embolism caused by hemiplegia, aphasia and myocardial infarction syndrome, arteriosclerosis, central retinitis, thrombophlebitis, varicose veins, edema caused by increased vascular permeability.
Last Update：2022-01-01 08:48:53
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-D-glucopyranoside - Water-soluble vitamins
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rutin is a kind of Vitamin p, which is the glycoside of dehydroflavone ketone. It is a hydrogen transporter that may be involved in the action of oxidoreductases in the body, which can affect the activity of the thyroid gland and protect epinephrine from oxidation. In the body can enhance the role of vitamin C and promote its accumulation in the body. Can maintain vascular elasticity, reduce its permeability, reduce its fragility. The mechanism is that hyaluronic acid is a matrix component in the intercellular substance of capillary wall. When it is hydrolyzed by hyaluronidase, the resistance of capillaries is reduced, the permeability and brittleness are increased, and bleeding is easily caused. Rutin can inhibit hyaluronidase, prevent hyaluronic acid hydrolysis, thereby enhancing the resistance of capillaries, reducing its permeability and brittleness. Rutin also promote cell proliferation, prevent blood cell agglutination, and diuretic, antitussive, hypolipidemic, antihypertensive, protective ulcer surface, anti-inflammatory and anti-allergic effect.
Last Update：2022-01-01 08:48:54
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-D-glucopyranoside - Chemical properties
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yellow small needle-like crystals (by Crystal Analysis). The color turned darker in light. Bitter taste. The melting point was 177-178 °c. Drying at 95-97 °c results in two molecules of crystalline water. After drying at 110 °c under vacuum (1.33 x 103Pa) for 12h, the product is anhydrous. Anhydrous easy deliquescence, melting point 190~192 ℃, in the atmosphere can absorb 2.5 molecules of water. In cold water solubility of 0.012%, hot water solubility of 5%. Slightly soluble in ethanol.
It has the function of normal blood vessel wall in animals. Can prevent arteriosclerosis. Together with hesperidin, the grass, as a vitamin P role of substances.
It is found in rutwood, buckwheat, Sophora japonica buds, tobacco leaves, leaves of Catalpa bungei, stems and leaves of tomato, etc. The content of the dried wheat at the time of flowering is about 3%.
Last Update：2022-01-01 08:48:54
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-D-glucopyranoside - Production method
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- rutin exists in the leaves of rutin, tobacco, orange peel, tomato, etc., and the contents of Sophora japonica and buckwheat flower are especially rich. Chinese medicinal rutin is extracted from Sophora japonica. After washing, with hot water and milk of lime (adjusted to pH 7.5-8) boiled for 20min, add borax, at 95-100 ℃ for half an hour, while hot filtration, the filtrate was adjusted to pH6-7 with hydrochloric acid, cooled to below 30 ° C., precipitated by standing, and separated to obtain crude rutin, which was dissolved, recrystallized and dried to obtain the finished product. The total yield was 8.3% based on Sophora japonica.
- the raw material (generally, the flower bud of Sophora japonica) was pulverized, extracted with hot ethanol, and purified by multiple crystallization from ether, hot methanol and hot water. The residue obtained after the concentration of the extract is removed from other insoluble substances such as soluble pigments with a solvent, and then purified by multiple crystallization and activated carbon from ethanol, ether, hot methanol and hot water.
Last Update：2022-01-01 08:48:55
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-D-glucopyranoside - Safety Information
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Mark Xn,Xi
Hazard code 22-36/37/38
Safety instructions 24/25-36-26
WGK Germany 3
RTECS# VM2975000
F 8
Last Update：2022-01-01 08:48:55
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-D-glucopyranoside - Role and use
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- Anti-inflammatory effect: intraperitoneal injection of rats has a significant inhibitory effect on the inflammatory process of the transplanted sheep hair bulb. The product of sodium sulfate (Sod. Rulin sulfate) on rat thermal edema has a strong anti-inflammatory effect.
- vitamin P-like effect, with the ability to maintain vascular resistance, reduce its permeability, reduce fragility and other effects, on fatty infiltration of the liver has a fat-removing effect, the effect of removing fat was more obvious when combined with glutathione.
- Anti-Virus effect: at a concentration of 200 μg/ml, there was a maximum inhibitory effect on vesicular stomatitis Virus.
- inhibition of aldose reductase: the inhibition rate was 95% at 10-5m concentration. This effect is beneficial to the treatment of diabetic cataract.
- Toxicity: mice were intravenously injected with LD50 950mg/kg.
- clinical: for the prevention and treatment of cerebral hemorrhage, hypertension, retinal hemorrhage, purulent and acute hemorrhagic nephritis. For the treatment of chronic tracheitis, the effective rates were 84.8% and 98% respectively. This product is a derivative of Tris (troxerutin ), namely weilutong, clinical for the treatment of burns, arthritis and a variety of vascular diseases, foreign goods have been sold. China has also been studied successfully, treatment of cerebrovascular disease effective rate 87.8%, treatment of retinal edema and hemorrhage effective rate 88%.
- Skin Care anti-aging effect:
- causes of skin aging
There are several mechanisms of skin aging: the collagen theory holds that skin aging is caused by the polymerization of collagen in the skin, but the reaction rate is greatly accelerated under ultraviolet light irradiation, resulting in accelerated skin aging. According to the theory of free radicals, skin aging is the result of the generation and elimination of free radicals, which can increase the formation of oxygen free radicals and cause a series of changes in skin under pathological or ultraviolet irradiation, for example, skin collagen fibers and elastic fibers lose elasticity and break, resulting in wrinkles, generation of melanin and generation of color spots.
- Anti-radiation effect of rutin
rutin has a strong absorption of ultraviolet and X-ray. As a natural sunscreen, adding 10% rutin, the absorption rate of ultraviolet is as high as 98%.
- Anti-free radical effect of rutin
oxygen molecules are reduced in the form of single electron in Cell Metabolism, oxygen molecules in the single electron reduction to produce O ions, the body then produces H2O2 and highly toxic · OH radicals, therefore, it affects the smoothness of the skin and even accelerates the degree of skin aging. The addition of rutin to the product can obviously remove the active oxygen radicals produced by the cells, and the clearance rate of Oi is as high as 78.1%, far greater than the effect of vitamin E(12.7%), but also on the OH scavenging effect is greater than that of vitamin E.
Last Update：2022-01-01 08:48:56
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-D-glucopyranoside - Skin Effects
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causes of skin aging
There are several mechanisms of skin aging: the collagen theory holds that skin aging is caused by the polymerization of collagen in the skin, but the reaction rate is greatly accelerated under ultraviolet light irradiation, resulting in accelerated skin aging. According to the theory of free radicals, skin aging is the result of the generation and elimination of free radicals, which can increase the formation of oxygen free radicals and cause a series of changes in skin under pathological or ultraviolet irradiation, for example, skin collagen fibers and elastic fibers lose elasticity and break, resulting in wrinkles, generation of melanin and generation of color spots.
Anti-radiation effect
rutin has a strong absorption of ultraviolet and X-ray. As a natural sunscreen, adding 10% rutin, the absorption rate of ultraviolet is as high as 98%.
Anti-free radical effect
oxygen molecules are reduced in the form of single electron in Cell Metabolism, oxygen molecules in the single electron reduction to produce O ions, the body then produces H2O2 and highly toxic · OH radicals, therefore, it affects the smoothness of the skin and even accelerates the degree of skin aging. The addition of rutin to the product can obviously remove the active oxygen radicals produced by the cells, and the clearance rate of Oi is as high as 78.1%, far greater than the effect of vitamin E(12.7%), but also on the OH scavenging effect is greater than that of vitamin E.
Last Update：2022-01-01 08:48:57
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-D-glucopyranoside - Physical properties
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light yellow needle crystals (water), melting point 176-8°C, 23D +13.82°C (ethanol),[]20d -39.43°C (pyridine). 1G dissolved in 7ml methanol, 8000ml water, 200ml boiling water, 23ml boiling ethanol, 290ml cold ethanol. UV & lambda; CH3OH max nm:258.361. IR & nu;KBr max cm-1 :3400(OH), 1670(C = O), 1620, 1520, 1470(C6H5-), insoluble in cold water, soluble in hot water, methanol, ethanol, pyridine, soluble in alkaline water.
description of character and quality of standard reference substance of rutin
light yellow to grass yellow powder; 1g can be dissolved in 8L water; 200ml boiling water; 7ml boiling methanol. Soluble in dimethyl sulfoxide and pyridine, formyl and alkali, ethanol-soluble; Acetone and ethyl acetate, almost insoluble in water, chloroform, ether, benzene, carbon disulfide and petroleum ether. Iron trichloride was green in dilute solution. No smell, under the action of light gradient dark, water soluble 12.5 mg/100. Melting Point: 195 °c.
note
The product is exposed to the air for a long time, the content will be reduced.
Quality description
- quality commitment: product quality problems caused by non-human, responsible for return and exchange.
- Quality control: in quality control, the following techniques are used.
- chromatography (high performance liquid chromatography: Thin layer chromatography; Gas chromatography)
- Mass spectrometry (LC-MS)
- spectrum (IR, UV), atomic absorption
- determination (determination of physical constants; Polarimetry; Determination of nonvolatile matter; Determination of loss on drying; Karl Fischer determination; Determination of evaporation or residue on ignition)
- Analysis (content analysis; Elemental analysis)
- titration (acid titration; Alkaline titration; Coordination titration; Non-aqueous titration; Redox titration)
- Test (mixed with water test; Clarity test; Chemical reaction test)
determination of total flavonoids in rutin granules by spectrophotometry
flavonoids are a class of natural products that widely exist in the plant kingdom. They have antioxidant and anti-free radical effects, and can be used for the treatment of cardiovascular and cerebrovascular diseases, tumors, inflammation and so on. Sophora japonica L contains a large number of flavonoids. In this study, Rutin and other flavonoids were extracted from Sophora japonica L by alkali extraction and acid precipitation, and rutin granules were prepared, the total flavonoids were determined by spectrophotometry. The experimental results show that the method is rapid, accurate and sensitive, and suitable for the control of the content of the effective part in the granules.
instruments and materials
- instrument
The instrument used in the experiment includes: 2802PC type UV scanner, UV 1800 type UV visible spectrophotometer, CT15RT type desktop high speed centrifuge, AS5150A ultrasonic cleaner.
- material
The materials used in the experiment include: the reference substance of rutin used in the experiment was provided by Guizhou Dida; The reagents used in the experiment were all analytically pure and were produced by Guizhou Di.
methods and results
determination method:
- preparation of rutin standard reference solution.
The rutin reference product 1O ITlg was accurately weighed, placed in a 50 mL measuring flask, dissolved in methanol, diluted to the scale, and shaken to prepare the reference solution.
- preparation of test solution.
take about 2 g of rutin granules, put them in a 50 mL measuring flask, add 20~30 mL of methanol, shake, ultrasonic 30s, dilute with methanol to the scale, A test solution was prepared.
- Method for Determination of flavonoids content.
Take 3 mL of rutin reference solution and 3 mL of sample solution respectively, separate them into 25 mL measuring flask, add 1 mL of 5% NaNO3 solution, and shake well, let stand for 6 min, add 10% Al(NO3) solution (1 mL), shake well, continue to stand for 6 min, add 4% NaOH solution (5 mL), dilute with distilled water to scale, shake well, let stand for 15 min, measure absorbance at 510 nm wavelength, As and. In addition, a reagent blank containing no flavone was prepared in a 25 mL measuring flask, and its absorbance at 510 nm wavelength was measured. The content of total flavonoids was calculated by the ratio of (a) and (a).
- Blank interference test.
Take 2 g of blank granules without rutin extract prepared according to the prescription, and operate according to the method described in Item "2.1.2" to prepare the test solution, centrifuge at 10 000 rpm for 5 min, take 3 mL of supernatant with precision, put it into 25 mL measuring flask, and operate as described in Item "2.1.3, scanning in the range of 200 600 pop wavelength, the results are shown in Figure 1. Rutin standard reference was also taken.
Last Update：2022-01-01 08:48:58
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-D-glucopyranoside - Introduction
Rutin is a natural flavonoid, mainly found in some plants, such as bitter orange, lemon, strawberry and so on. It has the following properties:
1. Nature: Rutin is colorless or light yellow crystal, soluble in hot water, ethanol and ether, insoluble in organic solvents. It has antioxidant, anti-inflammatory, antibacterial, anti-allergic activity.
2. Use: Rutin has a wide range of applications. In pharmacy, it is used as an antioxidant and anti-inflammatory agent, and is often used to treat cardiovascular diseases, anti-allergy, improve microcirculation, etc. In addition, Rutin can also be used in food and cosmetics, as a natural health product and beauty ingredient.
3. Preparation method: Rutin is usually obtained by plant extraction. A commonly used preparation method is to add a plant material (such as citrus peel) containing Rutin to an appropriate amount of solvent, and finally obtain pure Rutin through the steps of extraction, concentration, separation and purification.
4. Safety Information: Rutin is considered to be a relatively safe compound and rarely has significant adverse reactions at regular doses. However, in individual populations, such as pregnant or lactating women, as well as patients with specific diseases, it is best to consult a doctor's advice before use. In addition, for people with allergies, exposure to Rutin may cause allergic reactions, so care should be taken when using it.
1. Nature: Rutin is colorless or light yellow crystal, soluble in hot water, ethanol and ether, insoluble in organic solvents. It has antioxidant, anti-inflammatory, antibacterial, anti-allergic activity.
2. Use: Rutin has a wide range of applications. In pharmacy, it is used as an antioxidant and anti-inflammatory agent, and is often used to treat cardiovascular diseases, anti-allergy, improve microcirculation, etc. In addition, Rutin can also be used in food and cosmetics, as a natural health product and beauty ingredient.
3. Preparation method: Rutin is usually obtained by plant extraction. A commonly used preparation method is to add a plant material (such as citrus peel) containing Rutin to an appropriate amount of solvent, and finally obtain pure Rutin through the steps of extraction, concentration, separation and purification.
4. Safety Information: Rutin is considered to be a relatively safe compound and rarely has significant adverse reactions at regular doses. However, in individual populations, such as pregnant or lactating women, as well as patients with specific diseases, it is best to consult a doctor's advice before use. In addition, for people with allergies, exposure to Rutin may cause allergic reactions, so care should be taken when using it.
Last Update：2024-04-09 20:52:54
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View History
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-D-glucopyranoside
α-[2-(Diethylamino)ethyl]-α-isopropyl-1-naphthaleneacetonitrile
3-{[4-(4-methylphenyl)-1-piperazinyl]methyl}-5-(4-propoxybenzylidene)-1,3-thiazolidine-2,4-dione
B-(5-Phenyl-5H-benzo[b]carbazol-3-yl)boronic acid
ethyl 4-oxo-1,4-dihydro-1,6-naphthyridine-3-carboxylate
o-Dihydroxybenzene-13C6
5-(4-Bromophenyl)-1-(2-furylmethyl)-1H-imidazole-2-thiol
4-(3-bromo-4-isopropoxy-5-methoxybenzylidene)-2-(1-naphthyl)-1,3-oxazol-5(4H)-one
183251-95-8
4-(2,7-dibromo-9-(2,5-dimethylphenyl)-9H-fluoren-9-yl)phenol
α-[2-(Diethylamino)ethyl]-α-isopropyl-1-naphthaleneacetonitrile
3-{[4-(4-methylphenyl)-1-piperazinyl]methyl}-5-(4-propoxybenzylidene)-1,3-thiazolidine-2,4-dione
B-(5-Phenyl-5H-benzo[b]carbazol-3-yl)boronic acid
ethyl 4-oxo-1,4-dihydro-1,6-naphthyridine-3-carboxylate
o-Dihydroxybenzene-13C6
5-(4-Bromophenyl)-1-(2-furylmethyl)-1H-imidazole-2-thiol
4-(3-bromo-4-isopropoxy-5-methoxybenzylidene)-2-(1-naphthyl)-1,3-oxazol-5(4H)-one
183251-95-8
4-(2,7-dibromo-9-(2,5-dimethylphenyl)-9H-fluoren-9-yl)phenol