2-(((叔丁基二甲基甲基硅基)氧基)二苯基甲基)吡咯烷

2-(((叔丁基二甲基甲基硅基)氧基)二苯基甲基)吡咯烷 - Names and Identifiers

Name	Pyrrolidine, 2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]diphenylmethyl]-,(2S)-
Synonyms	(S)-[(diphenyl)-t-butyldimethylsiloxymethyl]pyrrolidine 2-(S)-[(DIPHENYL)(t-BUTYLDIMETHYLSILOXY)METHYL]PYRROLIDINE (S)-2-[(tert-ButyldiMethylsiloxy)diphenylMethyl]pyrrolidine S-2-[[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]DIPHENYLMETHYL]-PYRROLIDINE S-2-[[[(1,1-diMethylethyl)diMethylsilyl]oxy]diphenylMethyl]-Pyrrolidine (S)-(?)-α,α-Diphenyl-2-pyrrolidinemethanol tert-butyldimethylsilyl ether Pyrrolidine, 2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]diphenylmethyl]-,(2S)- (S)-(-)Alpha,Alpha-Diphenyl-2-Pyrrolidinemethanol Tert-Butyldimethylsilyl Ether
CAS	864466-71-7
InChIKey	YJFSFDYMOMREQP-NRFANRHFSA-N

2-(((叔丁基二甲基甲基硅基)氧基)二苯基甲基)吡咯烷 - Physico-chemical Properties

Molecular Formula	C23H33NOSi
Molar Mass	367.6
Density	0.998±0.06 g/cm3(Predicted)
Melting Point	71-73°C
Boling Point	445.2±35.0 °C(Predicted)
Flash Point	>110°C (>230°F)
BRN	10368174
pKa	10.12±0.10(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,Room temperature
Sensitive	7: reacts slowly with moisture/water

2-(((叔丁基二甲基甲基硅基)氧基)二苯基甲基)吡咯烷 - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3

2-(((叔丁基二甲基甲基硅基)氧基)二苯基甲基)吡咯烷 - Introduction

Pyrrolidine, 2-[[[(1,1-dimenthylethyl) dimethylsilyl]oxy]diphenylmethyl]-,(2S)-, often abbreviated as S-Binol-pyrrolidine, is an organic compound. Its chemical formula is C27H35NOSi.

Nature:
S-Binol-pyrrolidine is a white solid, odorless. It is soluble in most organic solvents such as ethanol, chloroform and dichloromethane. It has a high melting and boiling point.

Use:
S-Binol-pyrrolidine are mainly used in asymmetric catalytic reactions in organic synthesis. It can be used as a ligand for metal-catalyzed reactions, such as asymmetric vinylation, oxamide reaction and asymmetric cation insertion reaction. In addition, it can also be used to study chiral recognition and enantiomeric separation.

Preparation Method:
The preparation of S-Binol-pyrrolidine is usually accomplished by a two-step reaction. First, diphenyl methyl ketone is reacted with tert-butyldimethylaminosilane to produce diphenyl (tert-butyldimethylaminosiloxy) methyl ketone. This intermediate is then reacted with pyrrolidine to give the final product S-Binol-pyrrolidine.

Safety Information:
S-Binol-pyrrolidine there are no clear toxicity data. However, as an organic compound, it is still necessary to pay attention to safety measures, such as wearing appropriate protective gloves and glasses, and avoiding direct contact with skin and eyes. At the same time, it should be operated in a well-ventilated place, away from fire and high temperature environment. For accidental contact or ingestion, seek medical attention promptly.

Last Update：2024-04-10 22:29:15