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2,4-二羟基-3-硝基吡啶

2,4-Dihydroxy-3-nitropyridine

CAS: 89282-12-2

Molecular Formula: C5H4N2O4

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2,4-二羟基-3-硝基吡啶 - Names and Identifiers

Name 2,4-Dihydroxy-3-nitropyridine
Synonyms 3-nitropyridine-2,4-diol
3-NITRO-2,4-PYRIDINEDIOL
4-Dihydroxy-3-nitropyridine
2,4-Hydroxy-3-nitropyridine.
4-Hydroxy-3-nitro-2-pyridone
2,4-DIHYDROXY-3-NITROPYRIDINE
2,4-Dihydroxy-3-nitropyridine
2,4-dihydroxy 3-nitro pyridine
4,6-DIHYDROXY-5-NITRO PYRIDINE
2(1H)-Pyridinone, 4-hydroxy-3-nitro-
CAS 89282-12-2

2,4-二羟基-3-硝基吡啶 - Physico-chemical Properties

Molecular FormulaC5H4N2O4
Molar Mass156.1
Density1.65±0.1 g/cm3(Predicted)
Melting Point265°C (dec.)
Boling Point305.6±42.0 °C(Predicted)
AppearanceBright yellow crystal
BRN149558
pKa4.50±1.00(Predicted)
Storage ConditionInert atmosphere,Room Temperature
MDLMFCD01075671

2,4-二羟基-3-硝基吡啶 - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk Codes36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S37 - Wear suitable gloves.
UN IDs3335
HS Code29333990

2,4-二羟基-3-硝基吡啶 - Reference Information

introduction 2,4-dihydroxy -3-nitropyridine is white or light yellow solid at normal temperature and pressure. it belongs to pyridine heterocyclic compounds. due to the hydroxyl group in the structure, the enol structure is different to form a carbonyl structure to obtain the molecular structure of amide, it is a material additive and pharmaceutical chemical intermediate.
Use 2, 4-dihydroxy-3-nitropyridine can be used as a material additive, pharmaceutical chemistry and organic synthesis intermediate. In the synthetic transformation, the hydroxyl group in the structure may be affected by the influence of cyclopyridine and nitro group and can be easily converted into halogen atoms, it should be noted that by changing the reaction conditions, two hydroxyl groups can selectively halogenate one or convert two at one time. In addition, liquid bromine can be used to introduce a bromine atom at the 5th position of pyridine under acidic conditions.
synthesis 2, 4-dihydroxypyridine (13)(4.95kg, 43.2 mol) is slowly added into cooled (0-20 ℃) concentrated sulfuric acid (15 liters) in batches, and the reactants are stirred for 35 minutes, then slowly add fuming nitric acid (2L) at a rate of keeping the internal temperature below 5 degrees (adding time 4.5 hours), then add cold water (6 liters), and keep the internal temperature below 5 degrees (adding time 2.6 hours) and add the remaining 54 liters of water (adding time 1.25 hours) at a rate of raising the internal temperature to 15 degrees. The slurry is cooled to 8 degrees to obtain a precipitate, filtered (2 hours) and washed with water (2 × 20L), and the target product 2, 4-dihydroxy-3-nitropyridine is obtained by drying the solid in a 75-degree vacuum furnace under nitrogen atmosphere. Figure 2. Synthetic route of 4-dihydroxy-3-nitropyridine
Last Update：2024-04-09 20:52:54
2,4-二羟基-3-硝基吡啶
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Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: 2,4-Dihydroxy-3-nitropyridine Request for quotation
CAS: 89282-12-2
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Nantong Reform Petro-Chemical CO., LTD.
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Product Name: 2,4-Dihydroxy-3-nitropyridine Request for quotation
CAS: 89282-12-2
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Wechat: chemical6666 
SKYRUN INDUSTRIAL CO.,LTD
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Product Name: 24-Dihydroxy-3-nitropyridine Visit Supplier Webpage Request for quotation
CAS: 89282-12-2
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185 Click to send a QQ messageSend QQ message
Wechat: chinaskyrun
SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: 2,4-Dihydroxy-3-nitropyridine Visit Supplier Webpage Request for quotation
CAS: 89282-12-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
Shanghai Macklin Biochemical Co., Ltd
Spot supply
Product Name: 2,4-Dihydroxy-3-nitropyridine Visit Supplier Webpage Request for quotation
CAS: 89282-12-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple Specifications
Product Name: 2,4-Dihydroxy-3-Nitropyridine Visit Supplier Webpage Request for quotation
CAS: 89282-12-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Shanghai Worldyang Chemical Co.,Ltd.
Product Name: 2,4-Dihydroxy-3-nitropyridine Request for quotation
CAS: 89282-12-2
Tel: +86-21-56795779
Email: charles7788@worldyachem.com
Mobile: +86-13651600618
QQ: 2850607228 Click to send a QQ message
Wechat: +8613651600618
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View History
2,4-二羟基-3-硝基吡啶
PHOSPHORYLCHLORINECHLORIDECALCIUMSALTTETRAHYDRATE
1-氯-4-甲磺酰基-2-硝基-苯
7-氨基-1-甲基-1,3-二氢-2H-苯并[D]咪唑-2-酮
(5-氯-2-氟-4-甲基吡啶-3-基)硼酸
4-缇熷熀-2-鐢插熀鍚″暥
3-[2-[2-[2-[2-[2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
6-氨基-4-甲基-苯并吡喃-2-酮
2-甲基-4-甲氧基-5-氨基嘧啶
3-氨基-5-甲基-1H-吡咯-2-羧酸乙酯
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