2,3-Dimethoxy-5-((trimethylsilyl)ethynyl)pyridine
2,3-Dimethoxy-5-((trimethylsilyl)ethynyl)pyridine
CAS: 1171919-88-2
Molecular Formula: C12H17NO2Si
2,3-Dimethoxy-5-((trimethylsilyl)ethynyl)pyridine - Names and Identifiers
| Name | 2,3-Dimethoxy-5-((trimethylsilyl)ethynyl)pyridine |
| Synonyms | 2,3-Dimethoxy-5-((trimethylsilyl)ethynyl)pyridine Pyridine, 2,3-dimethoxy-5-[2-(trimethylsilyl)ethynyl]- |
| CAS | 1171919-88-2 |
2,3-Dimethoxy-5-((trimethylsilyl)ethynyl)pyridine - Physico-chemical Properties
| Molecular Formula | C12H17NO2Si |
| Molar Mass | 235.35 |
| Density | 1.02±0.1 g/cm3(Predicted) |
| Boling Point | 279.6±40.0 °C(Predicted) |
| pKa | 3.74±0.10(Predicted) |
| Storage Condition | 2-8℃ |
| Sensitive | IRRITANT |
| MDL | MFCD12401637 |
2,3-Dimethoxy-5-((trimethylsilyl)ethynyl)pyridine - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| Hazard Class | IRRITANT |
2,3-Dimethoxy-5-((trimethylsilyl)ethynyl)pyridine - Introduction
2,3-Dimethoxy-5-((trimethylsilyl)ethynyl)pyridine is an organic compound with a chemical formula of C13H19NOSi and a molecular weight of 241.38.
The following are the properties and uses of 2,3-Dimethoxy-5-((trimethylsilyl)ethynyl)pyridine:
Nature:
-Appearance: colorless liquid
-Solubility: Soluble in some organic solvents, such as ether, carbon disulfide and dimethylformamide.
-Melting point: about -19 to -21 ℃
-Boiling point: about 120 to 130 ℃
Use:
-It is widely used as a ligand or intermediate in organic synthesis because of its good electrophilicity and nucleophilicity.
-Used as a reagent for organometallic chemistry, for example, reacting with a platinum catalyst to obtain an amide platinum complex.
-Can be used to prepare some nitrogen-containing heterocyclic compounds, such as piperazine and pyridine derivatives.
Preparation Method:
The synthesis of 2,3-Dimethoxy-5-((trimethylsilyl)ethynyl)pyridine can be carried out by the following steps:
1. First, 2,3-dimethoxypyridine and diiodomethane are reacted under alkaline conditions to obtain 2,3-diiodomethoxypyridine.
2. Then, 2,3-diiodomethoxypyridine and trimethyl (silyl) acetylene are subjected to a reductive cross-coupling reaction in an organic solvent to obtain 2,3-Dimethoxy-5-((trimethylsilyl)ethynyl)pyridine.
Safety Information:
2,3-Dimethoxy-5-((trimethylsilyl)ethynyl)pyridine is an organic compound. Please take the following safety measures:
-Avoid inhalation, skin contact or ingestion of the compound.
-Wear protective glasses, protective gloves and protective clothing when in use.
-Store in a sealed container, away from fire and oxidizing agents.
-In case of accidental use or contact, seek medical help immediately and bring the compound's safety data sheet with you.
The following are the properties and uses of 2,3-Dimethoxy-5-((trimethylsilyl)ethynyl)pyridine:
Nature:
-Appearance: colorless liquid
-Solubility: Soluble in some organic solvents, such as ether, carbon disulfide and dimethylformamide.
-Melting point: about -19 to -21 ℃
-Boiling point: about 120 to 130 ℃
Use:
-It is widely used as a ligand or intermediate in organic synthesis because of its good electrophilicity and nucleophilicity.
-Used as a reagent for organometallic chemistry, for example, reacting with a platinum catalyst to obtain an amide platinum complex.
-Can be used to prepare some nitrogen-containing heterocyclic compounds, such as piperazine and pyridine derivatives.
Preparation Method:
The synthesis of 2,3-Dimethoxy-5-((trimethylsilyl)ethynyl)pyridine can be carried out by the following steps:
1. First, 2,3-dimethoxypyridine and diiodomethane are reacted under alkaline conditions to obtain 2,3-diiodomethoxypyridine.
2. Then, 2,3-diiodomethoxypyridine and trimethyl (silyl) acetylene are subjected to a reductive cross-coupling reaction in an organic solvent to obtain 2,3-Dimethoxy-5-((trimethylsilyl)ethynyl)pyridine.
Safety Information:
2,3-Dimethoxy-5-((trimethylsilyl)ethynyl)pyridine is an organic compound. Please take the following safety measures:
-Avoid inhalation, skin contact or ingestion of the compound.
-Wear protective glasses, protective gloves and protective clothing when in use.
-Store in a sealed container, away from fire and oxidizing agents.
-In case of accidental use or contact, seek medical help immediately and bring the compound's safety data sheet with you.
Last Update：2024-04-10 22:29:15
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2,3-Dimethoxy-5-((trimethylsilyl)ethynyl)pyridine
LZ-600酸性硅酮密封胶
Leveling agent SR-303
sodium [4-hydroxy-3-[(2-hydroxy-1-naphthyl)azo]benzenesulphonamidato(2-)][N-[7-hydroxy-8-[(2-hydroxy-5-nitrophenyl)azo]-1-naphthyl]methanesulphonamidato(2-)]chromate(1-)
PYR-RPPMEEEEEAYGWMDF-NH2
1-(1,1-二氟乙基)-4-丙基苯
N'-Boc-L-鸟氨酸甲酯盐酸盐
4-(2-甲氧苯基)-1,4-二氢[1,3,5]三嗪并[1,2-A]苯并咪唑-2-胺
LZ-600酸性硅酮密封胶
Leveling agent SR-303
sodium [4-hydroxy-3-[(2-hydroxy-1-naphthyl)azo]benzenesulphonamidato(2-)][N-[7-hydroxy-8-[(2-hydroxy-5-nitrophenyl)azo]-1-naphthyl]methanesulphonamidato(2-)]chromate(1-)
PYR-RPPMEEEEEAYGWMDF-NH2
1-(1,1-二氟乙基)-4-丙基苯
N'-Boc-L-鸟氨酸甲酯盐酸盐
4-(2-甲氧苯基)-1,4-二氢[1,3,5]三嗪并[1,2-A]苯并咪唑-2-胺