Molecular Formula | C14H19NO6 |
Molar Mass | 297.3 |
Density | 1.230±0.06 g/cm3(Predicted) |
Boling Point | 450.5±45.0 °C(Predicted) |
pKa | 1.47±0.70(Predicted) |
Storage Condition | Inert atmosphere,Room Temperature |
In vitro study | AV-153 free base causes IC 50 s for Raji and HL-60 cells of 14.9 mM and 10.3 mM, respectively. AV-153 free base (1 nM to 10 μM; 3 hours) reduces the level of spontaneously arising DNA single-strand breaks (SSBs) in peripheral blood lymphocytes or HL-60 cells by 13–67%. |
biological activity | AV-153 free base is a 1, 4-dihydroxypyridine (1,4-DHP) derivative with antimutagenic activity. In human cells in vitro, AV-153 free base can be inserted into a single strand break of DNA, reducing DNA damage and stimulating DNA repair. AV-153 free base can interact with thymine and cytosine and have an effect on poly (ADP) Ribosylation. AV-153 free base has anti-cancer activity. |